{"id":"W3204825643","doi":"10.1038/s41467-021-26059-4","title":"Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft; German Network for Bioinformatics Infrastructure; Helmholtz Association; European Commission; Heidelberger Stiftung Chirurgie; Bundesministerium für Bildung und Forschung; Deutsches Krebsforschungszentrum","keywords":"Organoid; Transcriptome; Biology; Cell; Cancer research; Progenitor cell; Computational biology; Wnt signaling pathway; Cell biology; Stem cell; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491833,0.0001096208,0.0002920887,0.0002885547,0.0001635639,0.000449318,0.0001172759,0.0001787869,0.0007520513],"category_scores_gemma":[0.000161096,0.00009377406,0.0001874899,0.0002765199,0.000153818,0.0001449426,0.0001993697,0.0004384794,0.000357039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823122,"about_ca_system_score_gemma":0.0001228279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236756,"about_ca_topic_score_gemma":0.000885886,"domain_scores_codex":[0.9998845,0.00001183352,0.000010599,0.00004315337,0.00003516561,0.00001470704],"domain_scores_gemma":[0.9998726,0.00004101746,0.00001694163,0.00002558005,0.00001892584,0.00002490394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009308929,0.00001277876,0.003054883,0.00002358301,0.000008369931,0.00005617015,0.00006391884,0.0001801495,0.9943926,0.00007349713,0.00006775058,0.001973284],"study_design_scores_gemma":[0.00001584429,0.0002612183,0.1026681,0.000009019809,0.00004625778,0.001164185,0.0003460835,0.004217809,0.8860697,0.0002943653,0.004888821,0.00001867305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835522,0.001017615,0.01157958,0.00007757908,0.0000114027,0.00003398313,0.002442045,0.0001415988,0.001144092],"genre_scores_gemma":[0.9914132,0.0005062548,0.004263717,0.00004806961,0.000004289622,0.00005069324,0.002714069,0.00003227542,0.0009675114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007520513,"threshold_uncertainty_score":0.002515912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03819069416514461,"score_gpt":0.3294202924166249,"score_spread":0.2912295982514803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}