{"id":"W3204859321","doi":"10.1186/s13063-021-05491-3","title":"Evaluating newly approved drugs for multidrug-resistant tuberculosis (endTB): study protocol for an adaptive, multi-country randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Engineers Without Borders Canada","funders":"Unitaid","keywords":"Medicine; Randomized controlled trial; Regimen; Interim analysis; Tuberculosis; Randomization; Intensive care medicine; Adverse effect; Clinical trial; Rifapentine; Moxifloxacin; Protocol (science); Internal medicine; Mycobacterium tuberculosis; Alternative medicine; Antibiotics; Latent tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0511943,0.007724858,0.010186,0.00190249,0.002931432,0.00507063,0.003696939,0.00744084,0.06433914],"category_scores_gemma":[0.0423247,0.003458925,0.005553458,0.003576836,0.004455333,0.004692977,0.002361066,0.008316589,0.0123543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00488313,"about_ca_system_score_gemma":0.0150281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001800655,"about_ca_topic_score_gemma":0.003901107,"domain_scores_codex":[0.9681453,0.02054412,0.003547583,0.003032304,0.002401204,0.00232957],"domain_scores_gemma":[0.9797703,0.005702718,0.004646455,0.003009511,0.004254736,0.0026163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9266937,0.005782957,0.001084958,0.01975566,0.003163077,0.0001978845,0.0003908009,0.001693302,0.001412167,0.004652603,0.01972323,0.0154497],"study_design_scores_gemma":[0.947678,0.01339677,0.002003839,0.003363432,0.001203633,0.00006069194,0.000111932,0.001619958,0.0005152135,0.002784589,0.02717591,0.00008598016],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001548314,0.000310497,0.001626207,0.0002578059,0.0003331892,0.9931866,0.001735994,0.0001060112,0.0008953557],"genre_scores_gemma":[0.001938166,0.0001172053,0.001972792,0.0002032543,0.00004482474,0.9951199,0.0002844359,0.000007491994,0.0003118437],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06433914,"threshold_uncertainty_score":0.2707446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3160762487777927,"score_gpt":0.5386381678082232,"score_spread":0.2225619190304305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}