{"id":"W3204862419","doi":"10.1371/journal.pgen.1009828","title":"Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase II","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; York University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"SUMO protein; Biology; RNA polymerase II; Transcription (linguistics); Transcription factor II D; Promoter; General transcription factor; Transcription factor II F; Chromatin immunoprecipitation; RNF4; Molecular biology; RNA polymerase II holoenzyme; Cell biology; Gene; Transcription factor; Genetics; Zinc finger; Ubiquitin; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033383,0.00029631,0.0003317116,0.0002190434,0.000182243,0.0005364065,0.0002157687,0.000194962,0.0016774],"category_scores_gemma":[0.0002645098,0.0002419485,0.0003831018,0.0001958509,0.0001982099,0.0002624737,0.0003041725,0.0003471856,0.0008964954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733289,"about_ca_system_score_gemma":0.000157399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007111002,"about_ca_topic_score_gemma":0.001373434,"domain_scores_codex":[0.9997914,0.00001560369,0.00001060695,0.00008873707,0.0000493463,0.00004433912],"domain_scores_gemma":[0.9998587,0.00002000083,0.00003537553,0.00002368724,0.00002264028,0.00003945459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008003008,0.000007296811,0.001897962,0.00003545929,0.000009239941,0.00004171631,0.00001508049,0.0001035666,0.9957722,0.00007251307,0.00006062867,0.00190423],"study_design_scores_gemma":[0.00001944486,0.0001288632,0.0666769,0.00001399258,0.00002894657,0.0003263011,0.0000889728,0.004326223,0.922505,0.000297138,0.005573105,0.00001505804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875001,0.002256816,0.007641415,0.00008841101,0.00004929142,0.00001238459,0.0003678744,0.0001889681,0.001894655],"genre_scores_gemma":[0.9953369,0.000569469,0.001901134,0.00005107319,0.00001814179,0.000008724586,0.0005977345,0.00004086268,0.001475956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016774,"threshold_uncertainty_score":0.00561142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721210025098044,"score_gpt":0.235032105814811,"score_spread":0.2178200055638306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}