{"id":"W3204862419","doi":"10.1371/journal.pgen.1009828","title":"Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase II","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; York University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"SUMO protein; Biology; RNA polymerase II; Transcription (linguistics); Transcription factor II D; Promoter; General transcription factor; Transcription factor II F; Chromatin immunoprecipitation; RNF4; Molecular biology; RNA polymerase II holoenzyme; Cell biology; Gene; Transcription factor; Genetics; Zinc finger; Ubiquitin; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007575181,0.0002206893,0.0001996965,0.00004331349,0.0001215052,0.00002529994,0.0001255587,0.0002149209,0.00009231499],"category_scores_gemma":[0.00002549146,0.0002321546,0.0001462963,0.0001119915,0.00008154068,0.000008375636,0.00003145744,0.00009903924,0.000003203945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002170799,"about_ca_system_score_gemma":0.00008727062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001128058,"about_ca_topic_score_gemma":0.00004469567,"domain_scores_codex":[0.9986581,0.0001151674,0.0003492089,0.0003908607,0.0002240589,0.000262621],"domain_scores_gemma":[0.999347,0.000006790672,0.00009611177,0.0003044756,0.0001487834,0.00009683434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004180884,0.0002474745,0.0006925251,0.00008866881,0.00007472926,0.000001191885,0.0005569012,0.00004126464,0.9967149,0.00001370318,0.0000853884,0.001441472],"study_design_scores_gemma":[0.0005145816,0.0004661148,0.0006020779,0.00002058031,0.0000628374,0.000004510747,0.0001309984,0.001340663,0.9947565,0.0001311281,0.001722952,0.0002471146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917043,0.005312247,0.001691501,0.0001164779,0.0001510732,0.0002728733,0.0005725345,0.00002036798,0.0001585982],"genre_scores_gemma":[0.9950562,0.0005693044,0.0009217163,0.00005356581,0.00005495088,0.00002112513,0.002354774,0.00003320023,0.0009351522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004742942,"threshold_uncertainty_score":0.9466991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721210025098044,"score_gpt":0.235032105814811,"score_spread":0.2178200055638306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}