{"id":"W3204865953","doi":"10.1101/2021.10.07.463539","title":"Development and characterization of influenza M2 ectodomain and/or HA stalk-based DC-targeting vaccines for different influenza infections","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Centre hospitalier de l'Université Laval; University of Manitoba","funders":"Research Manitoba","keywords":"Virology; Ectodomain; Influenza vaccine; Hemagglutinin (influenza); Biology; Vaccination; Vesicular stomatitis virus; Influenza A virus subtype H5N1; Recombinant DNA; Virus; Microbiology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524779,0.000265866,0.0001302554,0.0001157934,0.00007543932,0.000182264,0.0001463703,0.0002132528,0.0004797781],"category_scores_gemma":[0.00009608382,0.00007699001,0.000179854,0.00009381306,0.00007927876,0.000127485,0.00014008,0.0003163907,0.0002644052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151904,"about_ca_system_score_gemma":0.0001505838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822094,"about_ca_topic_score_gemma":0.0004520523,"domain_scores_codex":[0.9999323,0.00001047134,0.000008377655,0.00001293941,0.00001725415,0.00001866526],"domain_scores_gemma":[0.9999537,0.000003869712,0.000009423551,0.000007549049,0.00001184876,0.0000135726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003117611,0.00002016674,0.0002026216,0.00002332901,0.000003117009,0.00002107102,0.000004230146,0.00007135751,0.9986123,0.00004093526,0.00002635456,0.0009433652],"study_design_scores_gemma":[0.00001540973,0.000310805,0.002612418,0.0000056683,0.00001540951,0.0001819274,0.00001440755,0.001064196,0.9919044,0.00002241833,0.003850429,0.000002504269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873904,0.002237584,0.00829686,0.00009910193,0.00003478974,0.0001417608,0.0005827639,0.00003547882,0.001181183],"genre_scores_gemma":[0.9848742,0.001072722,0.009872127,0.00008995106,0.00001271771,0.00007485234,0.001848106,0.00001523837,0.002140244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004797781,"threshold_uncertainty_score":0.001605034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04930837924401215,"score_gpt":0.3072012081545702,"score_spread":0.2578928289105581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}