{"id":"W3204904358","doi":"10.1016/j.jchf.2021.06.011","title":"Drug Layering in Heart Failure","year":2021,"lang":"en","type":"review","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Servier; Deutsche Forschungsgemeinschaft; Impulse Dynamics; Biotronik; Cytokinetics; Boston Scientific Corporation; Boehringer Ingelheim; Amgen; Edwards Lifesciences; Patient-Centered Outcomes Research Institute; National Institutes of Health; Medtronic; Roche; Novartis; Pfizer; American Heart Association; Abbott Laboratories; Australian Carbon Innovation; Bayer; AstraZeneca","keywords":"Medicine; Heart failure; Ejection fraction; Intensive care medicine; Clinical trial; Internal medicine; Blood pressure; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006850317,0.001101376,0.004603122,0.0008184066,0.0001411625,0.0001549818,0.0002482042,0.0007469854,0.001619827],"category_scores_gemma":[0.0001414476,0.0009165224,0.001481548,0.001396807,0.00006806013,0.000207977,0.0003570046,0.001591935,0.001815125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713105,"about_ca_system_score_gemma":0.0009069205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001786105,"about_ca_topic_score_gemma":0.0008535907,"domain_scores_codex":[0.9950969,0.000415506,0.001273852,0.00133389,0.0007325154,0.001147298],"domain_scores_gemma":[0.9975297,0.0002358199,0.0001804985,0.001419412,0.0001164066,0.000518191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008439874,0.0003830089,0.0005849592,0.01631473,0.0004395555,0.0007692141,0.0001326074,0.000001261389,0.000005807241,0.0002016106,0.8835081,0.09765075],"study_design_scores_gemma":[0.0009831352,0.0000870818,0.00004039755,0.0270918,0.0009600923,0.0004683089,0.000205135,0.000002881312,0.000007839812,0.000006212117,0.969459,0.0006881095],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004959152,0.9594923,0.000007388687,0.03624837,0.0003831506,0.002957961,0.00002668982,0.0002806936,0.000553859],"genre_scores_gemma":[0.00005178178,0.9609994,0.02673548,0.001102094,0.001028405,0.0007201965,0.0006890717,0.0002661665,0.00840738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.09696264,"threshold_uncertainty_score":0.9993286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329464359512445,"score_gpt":0.3293869801514764,"score_spread":0.2964405442002319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}