{"id":"W3204904358","doi":"10.1016/j.jchf.2021.06.011","title":"Drug Layering in Heart Failure","year":2021,"lang":"en","type":"review","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Servier; Deutsche Forschungsgemeinschaft; Impulse Dynamics; Biotronik; Cytokinetics; Boston Scientific Corporation; Boehringer Ingelheim; Amgen; Edwards Lifesciences; Patient-Centered Outcomes Research Institute; National Institutes of Health; Medtronic; Roche; Novartis; Pfizer; American Heart Association; Abbott Laboratories; Australian Carbon Innovation; Bayer; AstraZeneca","keywords":"Medicine; Heart failure; Ejection fraction; Intensive care medicine; Clinical trial; Internal medicine; Blood pressure; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001333737,0.0009896311,0.002728419,0.002477254,0.0002355957,0.001605629,0.0009908656,0.001299183,0.007391701],"category_scores_gemma":[0.00205047,0.0004417001,0.001675829,0.00178781,0.0004722639,0.001590481,0.0009354883,0.002557555,0.001498401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006523115,"about_ca_system_score_gemma":0.001349515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001732672,"about_ca_topic_score_gemma":0.003950747,"domain_scores_codex":[0.999655,0.00007739378,0.00008632402,0.00004724999,0.00009638024,0.00003765111],"domain_scores_gemma":[0.9988896,0.0006431573,0.000270128,0.00002291111,0.0001220421,0.00005206314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002730305,0.000103364,0.0001788719,0.05099007,0.0007482236,0.0001122213,0.00003537626,0.0003071645,0.0007027425,0.002368194,0.02416836,0.9200124],"study_design_scores_gemma":[0.0007405904,0.0007642275,0.00263975,0.04452208,0.00537818,0.001083986,0.00007117677,0.0005170801,0.0007650954,0.004560031,0.9388868,0.00007096164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008731334,0.9989707,0.00007826471,0.0001933254,0.0001401585,0.000007338233,0.00002117488,0.000007950793,0.000493758],"genre_scores_gemma":[0.0008252694,0.9981064,0.0001845428,0.0003721787,0.0001569758,0.000008033292,0.00002653226,0.000001814627,0.0003183054],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007391701,"threshold_uncertainty_score":0.02472764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329464359512445,"score_gpt":0.3293869801514764,"score_spread":0.2964405442002319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}