{"id":"W3204914697","doi":"10.1016/j.biopsych.2021.09.020","title":"Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information","year":2021,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Actelion Pharmaceuticals; NIH Clinical Center; National Institute on Drug Abuse; National Institute of Mental Health; Walter Reed Army Institute of Research; National Institute on Aging; Statens Serum Institut; Medical Research Council; Metro North Hospital and Health Service; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Stanley Center for Psychiatric Research, Broad Institute; School of Medicine, Emory University; University of Texas Health Science Center at San Antonio; Perelman School of Medicine, University of Pennsylvania; School of Medicine, New York University; School of Medicine, University of North Carolina at Chapel Hill; National Institutes of Health; H. Lundbeck A/S; University of Cape Town; McDonnell Center for Systems Neuroscience; Universitetet i Oslo; Region Hovedstaden; Leids Universitair Medisch Centrum; Universiteit Stellenbosch; RTI International; Queensland University of Technology; Maastricht Universitair Medisch Centrum; York University; Universiteit Leiden; South African Medical Research Council; University of South Carolina; Gallipoli Medical Research Foundation; NIHR Maudsley Biomedical Research Centre; Otsuka America; Cohen Veterans Bioscience; American Society of Clinical Psychopharmacology; Broad Institute; University of New South Wales; Universiteit Maastricht; Genentech; Indivior; Emory University; Jazz Pharmaceuticals; Arbor Pharmaceuticals; King's College London; Louisiana State University; University of Minnesota; Mailman School of Public Health, Columbia University; Universitair Medisch Centrum Utrecht; ACADIA Pharmaceuticals; Case Western Reserve University; Uniformed Services University of the Health Sciences; One Mind; U.S. Department of Veterans Affairs; University of Pennsylvania; GW Pharmaceuticals; Kent State University; U.S. Army Medical Research and Development Command; University of North Carolina at Chapel Hill; Harvard University; Vrije Universiteit Amsterdam; Campbell Family Mental Health Research Institute; University of South Florida; Medical School, University of Michigan; QIMR Berghofer Medical Research Institute; Aarhus Universitetshospital; Takeda Pharmaceuticals U.S.A.; Aarhus Universitet; Lundbeckfonden; Faculty of Medicine and Health, University of Sydney; Cardiff University; U.S. Department of Defense; McLean Hospital; University of Toronto; Yale University; Brain and Behavior Research Foundation; Sunovion; University of Washington; Universidade de Lisboa; Northern Illinois University; School of Medicine, Duke University; Biogen; National Center for PTSD, U.S. Department of Veterans Affairs; Gentofte Hospital; U.S. Army; School of Medicine, Boston University","keywords":"Posttraumatic stress; Phenotype; Psychology; Clinical psychology; Medicine; Computational biology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006065434,0.0007543557,0.0006016444,0.001723789,0.0003793873,0.001301647,0.0008220652,0.0006673303,0.00286805],"category_scores_gemma":[0.01215041,0.0004055608,0.001851263,0.002351289,0.0005043662,0.0004933726,0.001111051,0.0009409532,0.000236307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257754,"about_ca_system_score_gemma":0.0007457102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002968055,"about_ca_topic_score_gemma":0.004151977,"domain_scores_codex":[0.997541,0.001352546,0.0001258914,0.0006401148,0.0002306395,0.0001097939],"domain_scores_gemma":[0.989755,0.006892852,0.001553659,0.001058319,0.0004361201,0.0003040437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001473699,0.0002451679,0.8907375,0.0006196729,0.006251164,0.0006404416,0.0003980563,0.005479074,0.01922274,0.00231985,0.001554858,0.07105769],"study_design_scores_gemma":[0.0004979083,0.0007833682,0.9538149,0.0002046403,0.00506388,0.001123408,0.0001475883,0.01938264,0.00432883,0.01044118,0.00413015,0.00008153828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9298108,0.003544057,0.05837653,0.001891228,0.0001045398,0.00009611694,0.004217783,0.0004029168,0.001556084],"genre_scores_gemma":[0.9673777,0.0005774434,0.03020157,0.000321927,0.0000757007,0.00007174556,0.001024727,0.00005798763,0.0002911912],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006065434,"threshold_uncertainty_score":0.03207743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05053307660054467,"score_gpt":0.3451176780043509,"score_spread":0.2945846014038062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}