{"id":"W3204914697","doi":"10.1016/j.biopsych.2021.09.020","title":"Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information","year":2021,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Actelion Pharmaceuticals; NIH Clinical Center; National Institute on Drug Abuse; National Institute of Mental Health; Walter Reed Army Institute of Research; National Institute on Aging; Statens Serum Institut; Medical Research Council; Metro North Hospital and Health Service; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Stanley Center for Psychiatric Research, Broad Institute; School of Medicine, Emory University; University of Texas Health Science Center at San Antonio; Perelman School of Medicine, University of Pennsylvania; School of Medicine, New York University; School of Medicine, University of North Carolina at Chapel Hill; National Institutes of Health; H. Lundbeck A/S; University of Cape Town; McDonnell Center for Systems Neuroscience; Universitetet i Oslo; Region Hovedstaden; Leids Universitair Medisch Centrum; Universiteit Stellenbosch; RTI International; Queensland University of Technology; Maastricht Universitair Medisch Centrum; York University; Universiteit Leiden; South African Medical Research Council; University of South Carolina; Gallipoli Medical Research Foundation; NIHR Maudsley Biomedical Research Centre; Otsuka America; Cohen Veterans Bioscience; American Society of Clinical Psychopharmacology; Broad Institute; University of New South Wales; Universiteit Maastricht; Genentech; Indivior; Emory University; Jazz Pharmaceuticals; Arbor Pharmaceuticals; King's College London; Louisiana State University; University of Minnesota; Mailman School of Public Health, Columbia University; Universitair Medisch Centrum Utrecht; ACADIA Pharmaceuticals; Case Western Reserve University; Uniformed Services University of the Health Sciences; One Mind; U.S. Department of Veterans Affairs; University of Pennsylvania; GW Pharmaceuticals; Kent State University; U.S. Army Medical Research and Development Command; University of North Carolina at Chapel Hill; Harvard University; Vrije Universiteit Amsterdam; Campbell Family Mental Health Research Institute; University of South Florida; Medical School, University of Michigan; QIMR Berghofer Medical Research Institute; Aarhus Universitetshospital; Takeda Pharmaceuticals U.S.A.; Aarhus Universitet; Lundbeckfonden; Faculty of Medicine and Health, University of Sydney; Cardiff University; U.S. Department of Defense; McLean Hospital; University of Toronto; Yale University; Brain and Behavior Research Foundation; Sunovion; University of Washington; Universidade de Lisboa; Northern Illinois University; School of Medicine, Duke University; Biogen; National Center for PTSD, U.S. Department of Veterans Affairs; Gentofte Hospital; U.S. Army; School of Medicine, Boston University","keywords":"Posttraumatic stress; Phenotype; Psychology; Clinical psychology; Medicine; Computational biology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458681,0.0002663836,0.001036939,0.0000469959,0.00005481018,0.00001447671,0.0001509887,0.0005849109,0.000005939344],"category_scores_gemma":[0.0005544077,0.0001884399,0.0003254981,0.0001121882,0.0001191276,0.00001351701,0.00007003421,0.0001050684,6.765395e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000975698,"about_ca_system_score_gemma":0.0001482113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002799781,"about_ca_topic_score_gemma":0.0000754126,"domain_scores_codex":[0.9981323,0.0002736681,0.001034356,0.0003063578,0.0000687214,0.0001845906],"domain_scores_gemma":[0.9985151,0.0001834756,0.0008868205,0.0002389801,0.0001487121,0.00002688153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002035342,0.0009597837,0.01082033,0.02271615,0.00190289,3.534617e-7,0.0008459731,0.00007764622,0.001615078,0.01623988,0.0006380519,0.9439803],"study_design_scores_gemma":[0.0106059,0.04020994,0.2682782,0.05693554,0.009164206,0.0001613161,0.02856555,0.0004094455,0.002162836,0.02970465,0.5452368,0.008565707],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0472341,0.8961745,0.05494572,0.00002534911,0.0003118271,0.0006384161,0.0006161972,0.000004247223,0.00004964501],"genre_scores_gemma":[0.01813053,0.922544,0.05693819,0.0000452686,0.000101819,0.0001004688,0.002108592,0.00001529794,0.0000158298],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9354146,"threshold_uncertainty_score":0.7684356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05053307660054467,"score_gpt":0.3451176780043509,"score_spread":0.2945846014038062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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