{"id":"W3205000511","doi":"10.1128/aem.01515-21","title":"Engineering a Lysin with Intrinsic Antibacterial Activity (LysMK34) by Cecropin A Fusion Enhances Its Antibacterial Properties against Acinetobacter baumannii","year":2021,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Vlaamse regering; Universiteit Antwerpen; Cultural Affairs and Missions Sector, Ministry of Higher Education; Fonds Wetenschappelijk Onderzoek","keywords":"Acinetobacter baumannii; Lysin; Microbiology; Acinetobacter; Antibacterial activity; Biology; Bacteria; Bacteriophage; Antibiotics; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268548,0.0002782715,0.0001470301,0.0001240271,0.0001020795,0.0002572241,0.000148113,0.0003170614,0.0005780978],"category_scores_gemma":[0.0001500733,0.00007718864,0.0001854702,0.0001513961,0.0001971811,0.0001833596,0.0002254262,0.0004402255,0.0002275874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348732,"about_ca_system_score_gemma":0.0001443053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005402355,"about_ca_topic_score_gemma":0.0004517117,"domain_scores_codex":[0.9998842,0.0000212593,0.00001293516,0.00001896049,0.00002818286,0.00003442445],"domain_scores_gemma":[0.999905,0.00001513794,0.00003395373,0.000008436975,0.00001082668,0.0000265533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005433864,0.00002405982,0.00007072552,0.00000947656,0.000002252231,0.00003498146,0.000006368934,0.0001392829,0.9990149,0.0000424883,0.00001598782,0.0005851046],"study_design_scores_gemma":[0.000009182017,0.0002216837,0.001283663,0.000003416441,0.000008334497,0.0001499055,0.00001571125,0.001283299,0.9958935,0.00001452332,0.001111553,0.000005231346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971833,0.0001660933,0.00200014,0.00006016723,0.00001379816,0.00001219316,0.00006902603,0.00003551093,0.0004598285],"genre_scores_gemma":[0.996986,0.000097249,0.002070648,0.0000258639,0.000003415639,0.000008664536,0.00011385,0.000014823,0.0006795809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005780978,"threshold_uncertainty_score":0.001933932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004581294815933683,"score_gpt":0.1551800631234282,"score_spread":0.1505987683074945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}