{"id":"W3205050915","doi":"10.20944/preprints202108.0365.v1","title":"Concern for <em>Dirofilaria immitis</em> and Macrocyclic Lactone Loss of Efficacy: Current Situation in the USA and Europe, and Future Scenarios","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Dirofilaria immitis; Resistance (ecology); Medicine; Biology; Veterinary medicine; Helminths; Immunology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006414102,0.0004060397,0.0007437157,0.0001623636,0.0001046765,0.00007885472,0.0002201225,0.0002207682,0.0001782141],"category_scores_gemma":[0.0005854741,0.0003181374,0.0001375576,0.0001873378,0.0002635858,0.00008795104,0.0007774789,0.0006173318,0.0000263921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009353937,"about_ca_system_score_gemma":0.0003470335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001006807,"about_ca_topic_score_gemma":0.0003013607,"domain_scores_codex":[0.9971253,0.0003131689,0.0005369529,0.0009978964,0.0005893739,0.0004373152],"domain_scores_gemma":[0.9979463,0.0003509211,0.0002434885,0.000818295,0.000305181,0.0003358517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00142201,0.001613097,0.9471632,0.002301479,0.0006908412,0.0003822879,0.004890344,0.00002104145,0.008127863,0.0004267222,0.00009107085,0.03287],"study_design_scores_gemma":[0.00449098,0.0001325713,0.988517,0.0007202761,0.0004383734,0.00008143174,0.00032474,0.0002665934,0.001857384,0.0001405813,0.002774856,0.0002551509],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854521,0.01002414,0.00006597617,0.0009219215,0.0001975797,0.002647061,0.0002370841,0.00002366964,0.0004304505],"genre_scores_gemma":[0.9882802,0.01027069,0.0001151865,0.00008112622,0.0002578387,0.0003118154,0.0004801315,0.00003758108,0.0001654168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04135382,"threshold_uncertainty_score":0.999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08083313266224636,"score_gpt":0.3802619905452154,"score_spread":0.299428857882969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}