{"id":"W3205109108","doi":"10.1016/j.cjca.2021.07.019","title":"REGULATION OF CARDIAC ION CHANNELS VIA STRESS SIGNALING","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Ryanodine receptor; Ryanodine receptor 2; Endoplasmic reticulum; Cav1.2; Protein kinase A; Cell biology; Ion channel; Calmodulin; Voltage-dependent calcium channel; Phosphorylation; Signal transduction; Calcium signaling; Allosteric regulation; Receptor; Biochemistry; Biophysics; Calcium; Biology; Medicine; Enzyme; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630943,0.000359302,0.0001993608,0.0001832215,0.0003398737,0.0007012626,0.0002592114,0.0003704948,0.001156598],"category_scores_gemma":[0.0002139779,0.0001197602,0.0002342327,0.0001076338,0.0003791121,0.0004353014,0.0004386214,0.0006214571,0.000208957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007019399,"about_ca_system_score_gemma":0.0003217806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346916,"about_ca_topic_score_gemma":0.001905078,"domain_scores_codex":[0.9998767,0.00001738453,0.00000657251,0.00002501661,0.00002847151,0.00004575106],"domain_scores_gemma":[0.9998338,0.00002105296,0.00004417605,0.00001297929,0.00003231024,0.00005554636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002918238,0.00002809324,0.0007267148,0.00004914435,0.000008866223,0.0002779372,0.00008187042,0.0001522066,0.9922568,0.001921291,0.0003622478,0.003843108],"study_design_scores_gemma":[0.0001521484,0.0007993479,0.1035729,0.0000804948,0.00008155635,0.00127093,0.000877876,0.006651813,0.8628803,0.006850931,0.01670559,0.00007610744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612972,0.01273276,0.01029311,0.003098227,0.0004188279,0.00005203971,0.0005733689,0.0002119005,0.01132245],"genre_scores_gemma":[0.9921036,0.003900475,0.0009621621,0.0003131248,0.00006792853,0.00002041554,0.0001684733,0.0000172346,0.002446651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346916,"threshold_uncertainty_score":0.005092919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113440749314799,"score_gpt":0.215941840205848,"score_spread":0.2045977652743681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}