{"id":"W3205169317","doi":"10.1021/acs.jmedchem.1c00889","title":"Structure–Activity Relationship of USP5 Inhibitors","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto","funders":"Structural Genomics Consortium; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología; Huntington's Disease Society of America","keywords":"Ubiquitin; Chemistry; Deubiquitinating enzyme; Structure–activity relationship; In vitro; Zinc finger; Biochemistry; Cell biology; Stereochemistry; Computational biology; Gene; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005598756,0.0008345314,0.0005079284,0.0005337203,0.0002982222,0.0004025497,0.0005188477,0.000378615,0.004488372],"category_scores_gemma":[0.0004142053,0.0002749767,0.000399923,0.0005447462,0.000235853,0.0002777962,0.0002004424,0.0007486527,0.0007886273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009170726,"about_ca_system_score_gemma":0.0006546826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001806565,"about_ca_topic_score_gemma":0.003377195,"domain_scores_codex":[0.9996139,0.00008911325,0.00002859515,0.00005283372,0.000136338,0.00007923251],"domain_scores_gemma":[0.9998183,0.00004407356,0.00004194266,0.00001916011,0.00004308932,0.00003342493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000881265,0.0004439468,0.000911848,0.0003159613,0.0001365789,0.0001430468,0.00006140671,0.003314176,0.9710364,0.001888082,0.001485388,0.01938181],"study_design_scores_gemma":[0.0001791982,0.002325459,0.001967598,0.00002979337,0.0001303828,0.0003660705,0.00003344159,0.004811401,0.9792245,0.0003258809,0.01057387,0.00003237743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8873358,0.03804697,0.03198118,0.001111601,0.0003871713,0.000650259,0.005949199,0.0006322486,0.0339057],"genre_scores_gemma":[0.9746758,0.006144196,0.007239645,0.0002770995,0.00004211494,0.0001298638,0.004642535,0.00002383228,0.006824941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004488372,"threshold_uncertainty_score":0.01501513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418334648218127,"score_gpt":0.2592166054996515,"score_spread":0.2450332590174703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}