{"id":"W3205195294","doi":"10.1038/s41588-021-00928-6","title":"Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; Wellcome Trust; Japan Agency for Medical Research and Development; Medical Research Council; Wellcome; Alfred P. Sloan Foundation; World Health Organization; National Cancer Institute; Cancer Research UK; U.S. Department of Health and Human Services","keywords":"Biology; Incidence (geometry); Esophageal squamous cell carcinoma; Basal cell; Carcinoma; Genetics; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005346877,0.0001891511,0.0001523502,0.00004108898,0.00006678561,0.00005585685,0.0001876322,0.0004158797,0.00005836378],"category_scores_gemma":[0.00007857112,0.0001875096,0.00004586875,0.0001383548,0.00006369364,0.000003423731,0.0001189297,0.0003525716,0.000004010138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004000012,"about_ca_system_score_gemma":0.0005280224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004599513,"about_ca_topic_score_gemma":0.0005725088,"domain_scores_codex":[0.9988379,0.00003413799,0.0001861901,0.0004558453,0.0002379694,0.0002479233],"domain_scores_gemma":[0.999225,0.00008851361,0.00007338759,0.0003169425,0.000217771,0.00007834323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008945249,0.000476701,0.5408948,0.000159737,0.00009775396,0.002631189,0.0009469222,0.06119365,0.3794721,0.0004283928,0.01140702,0.001397237],"study_design_scores_gemma":[0.001545496,0.0001981594,0.1212744,0.00001606632,0.00004401661,0.00002782913,0.00006399384,0.0004779827,0.8638096,0.000389026,0.01175845,0.0003949486],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495383,0.04852754,0.0003483997,0.0001274215,0.0002754868,0.0001099745,0.0002616455,0.000005305325,0.0008059317],"genre_scores_gemma":[0.9917236,0.0004414155,0.005071674,0.00147011,0.0004827172,0.00001215808,0.0005977664,0.00003017125,0.000170389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4843375,"threshold_uncertainty_score":0.764642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00359147797081183,"score_gpt":0.2176527204900845,"score_spread":0.2140612425192726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}