{"id":"W3205195294","doi":"10.1038/s41588-021-00928-6","title":"Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; Wellcome Trust; Japan Agency for Medical Research and Development; Medical Research Council; Wellcome; Alfred P. Sloan Foundation; World Health Organization; National Cancer Institute; Cancer Research UK; U.S. Department of Health and Human Services","keywords":"Biology; Incidence (geometry); Esophageal squamous cell carcinoma; Basal cell; Carcinoma; Genetics; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005415471,0.0002156568,0.000349286,0.001523562,0.0002961222,0.0006517131,0.0001634664,0.0002728158,0.0005745838],"category_scores_gemma":[0.001719556,0.0002251371,0.0003927089,0.002008803,0.0002990824,0.0001834215,0.0005395259,0.0001766584,0.0001096133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601269,"about_ca_system_score_gemma":0.0001654209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00483478,"about_ca_topic_score_gemma":0.00574944,"domain_scores_codex":[0.9994174,0.0001868757,0.00007213568,0.000157745,0.00007993027,0.0000859854],"domain_scores_gemma":[0.9991657,0.0002047919,0.000299439,0.0001189663,0.0001457548,0.00006534764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001626033,0.00001153537,0.9905272,0.00004337869,0.0002040925,0.0002047508,0.0003580345,0.000252653,0.003432066,0.00004008737,0.00008527954,0.004678468],"study_design_scores_gemma":[0.000004277507,0.00004665905,0.9982243,0.00000937857,0.00005984163,0.0004101666,0.000422417,0.00009734984,0.0003759789,0.00001478081,0.000330653,0.000004193356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989836,0.0001779899,0.0001016895,0.000007564603,0.000001312014,0.000005210238,0.0005335134,0.00000259097,0.0001865501],"genre_scores_gemma":[0.998508,0.0001381477,0.0002367616,0.00001446634,0.000001207157,0.000006956095,0.001027571,0.000002982037,0.00006374266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00483478,"threshold_uncertainty_score":0.009613276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00359147797081183,"score_gpt":0.2176527204900845,"score_spread":0.2140612425192726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}