{"id":"W3205241737","doi":"10.14740/cii137","title":"Metformin Regulates the Inflammatory Response of Human Monocytes to SARS-CoV-2 Spike Glycoprotein","year":2021,"lang":"en","type":"article","venue":"Clinical Infection and Immunity","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Proinflammatory cytokine; Immunology; Medicine; Metformin; Inflammation; Immune system; Interferon; Cytokine storm; Coronavirus disease 2019 (COVID-19); Disease; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115884,0.0001497628,0.0001915345,0.0001568459,0.0001388581,0.0002367194,0.0000838687,0.0001967264,0.002005468],"category_scores_gemma":[0.00018744,0.00007308828,0.0001844643,0.0001423133,0.00009885647,0.00008540968,0.0001201373,0.000332767,0.0003085004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572532,"about_ca_system_score_gemma":0.0002707077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003516826,"about_ca_topic_score_gemma":0.0006696152,"domain_scores_codex":[0.9998978,0.00002947427,0.000009498805,0.00001147695,0.00001778588,0.00003386171],"domain_scores_gemma":[0.9999381,0.00001295321,0.00001595701,0.000004133452,0.00001294834,0.00001580916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01446163,0.001540425,0.01167939,0.0004606041,0.00005239526,0.0004861132,0.0001530197,0.0001814762,0.9367979,0.0002400662,0.001378275,0.03256877],"study_design_scores_gemma":[0.00227023,0.02767897,0.2852971,0.0001178562,0.0002799465,0.001407518,0.0006625883,0.001808454,0.6614668,0.0003555109,0.01861778,0.00003728085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939808,0.004075472,0.0002015003,0.0002045542,0.00007843965,0.00005591231,0.0002824591,0.00001128077,0.001109696],"genre_scores_gemma":[0.9945696,0.002448753,0.0005376132,0.000185235,0.0000509769,0.00008951445,0.0004851526,0.000003352954,0.001629851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005468,"threshold_uncertainty_score":0.00670892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1458688422272001,"score_gpt":0.4958965378018242,"score_spread":0.3500276955746241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}