{"id":"W3205275001","doi":"10.1093/intbio/zyab015","title":"Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy","year":2021,"lang":"en","type":"article","venue":"Integrative Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Promoter; Embryonic stem cell; Inflammation; Biology; Genetic enhancement; Synthetic biology; Cell biology; HEK 293 cells; Gene; Computational biology; Gene expression; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003464636,0.0003765094,0.00036019,0.0001810745,0.0001548432,0.0003489033,0.0002363917,0.0003826503,0.0008305751],"category_scores_gemma":[0.0003332953,0.0001527313,0.0002919969,0.0002099543,0.0003499924,0.0002961934,0.0002741233,0.0007062932,0.0005257798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002814259,"about_ca_system_score_gemma":0.000436549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002514314,"about_ca_topic_score_gemma":0.00034408,"domain_scores_codex":[0.9997249,0.00003688646,0.00002642673,0.00007248867,0.00009247106,0.00004669663],"domain_scores_gemma":[0.9998203,0.00004093962,0.00005861574,0.00002264265,0.00002929134,0.00002821995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002446491,0.000009432685,0.00005066483,0.00004560207,0.00000154402,0.00002620155,0.00001773611,0.0001056088,0.9980444,0.0002667463,0.00002840137,0.001379126],"study_design_scores_gemma":[0.000006421292,0.00008222499,0.0001615302,0.000005610833,0.000006194956,0.00008945489,0.00000963259,0.0007129875,0.9943374,0.00007284695,0.004511214,0.000004623319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6644078,0.003477566,0.3236168,0.0003243088,0.0002502609,0.0004547782,0.001154696,0.0007762873,0.005537547],"genre_scores_gemma":[0.8275289,0.003091236,0.1607165,0.0001515618,0.00005776503,0.0004650627,0.001835665,0.0002414224,0.005911806],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0008305751,"threshold_uncertainty_score":0.00277853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634017173656337,"score_gpt":0.2861608664847711,"score_spread":0.2698206947482077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}