{"id":"W3205275001","doi":"10.1093/intbio/zyab015","title":"Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy","year":2021,"lang":"en","type":"article","venue":"Integrative Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Promoter; Embryonic stem cell; Inflammation; Biology; Genetic enhancement; Synthetic biology; Cell biology; HEK 293 cells; Gene; Computational biology; Gene expression; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357355,0.0001267927,0.0001833016,0.00004035424,0.0000405857,0.00001052343,0.0001223376,0.0001910053,0.00008883743],"category_scores_gemma":[0.0002665193,0.00009659011,0.0001124021,0.00006783183,0.00007750643,0.000005816216,0.00003374095,0.00005257846,0.000007500487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011573,"about_ca_system_score_gemma":0.0001378055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002877542,"about_ca_topic_score_gemma":0.00007319067,"domain_scores_codex":[0.9991888,0.0001049015,0.0002188994,0.0002929241,0.00003520399,0.0001592723],"domain_scores_gemma":[0.9990638,0.0000691379,0.0001139373,0.0002290083,0.0004984771,0.00002567373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001602218,0.00007131293,0.001244168,0.00001123977,0.0000643638,4.655383e-7,0.000155775,0.000002726868,0.9878945,0.0006191352,0.0007949849,0.008981065],"study_design_scores_gemma":[0.0003230726,0.000851373,0.000270173,0.00001476614,0.000009510859,0.000003031066,0.0003742434,0.00002978475,0.9743171,0.0005445405,0.02315631,0.0001060821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808173,0.0008190983,0.01442675,0.0001783091,0.0001386392,0.0002421113,0.00008762153,0.00000606776,0.003284143],"genre_scores_gemma":[0.9957221,0.0002626942,0.001835406,0.00006763607,0.000142454,0.0001609681,0.0003032628,0.00001096921,0.001494581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02236133,"threshold_uncertainty_score":0.393883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634017173656337,"score_gpt":0.2861608664847711,"score_spread":0.2698206947482077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}