{"id":"W3205334196","doi":"10.1159/000519857","title":"Functional Analysis of SCN5A Genetic Variants Associated with Brugada Syndrome","year":2021,"lang":"en","type":"article","venue":"Cardiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Brugada syndrome; Sodium channel; Nav1.5; Electrophysiology; Heterologous expression; Voltage clamp; Western blot; Patch clamp; Mutation; Biology; Genetics; Chemistry; Sodium; Cell biology; Molecular biology; Internal medicine; Gene; Medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002277022,0.0005417286,0.0002090407,0.0009389203,0.0002186701,0.0002142033,0.0002248711,0.0004976144,0.001779724],"category_scores_gemma":[0.0006059166,0.00008079572,0.0003367111,0.0003919071,0.000311654,0.0001078976,0.0002602013,0.0002303358,0.0002354364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579529,"about_ca_system_score_gemma":0.0001007878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009321971,"about_ca_topic_score_gemma":0.000808908,"domain_scores_codex":[0.9997451,0.00003827696,0.00004604652,0.00008362993,0.00005529599,0.00003176587],"domain_scores_gemma":[0.999604,0.0001275629,0.0001412248,0.00001502699,0.00003902532,0.00007317933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001305943,0.0001320408,0.419784,0.0001766961,0.0002664644,0.03287958,0.0005106477,0.0006179574,0.5340278,0.0003358578,0.0003209512,0.009641953],"study_design_scores_gemma":[0.00007401322,0.0008274243,0.8782268,0.00005708782,0.0002995824,0.06098334,0.0004807473,0.003069113,0.05347229,0.0003029173,0.002179387,0.00002723288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986235,0.0003014575,0.0004546648,0.00002580294,0.00001251352,0.000009399964,0.0002483738,0.00001031856,0.0003139601],"genre_scores_gemma":[0.9991197,0.00007132878,0.0004452368,0.00002216036,0.000005433043,0.000004489223,0.0002560848,0.000005737709,0.00006981527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779724,"threshold_uncertainty_score":0.005953789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100326815393527,"score_gpt":0.2229740530718392,"score_spread":0.2129413715324865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}