{"id":"W3205408718","doi":"10.1016/j.cell.2021.09.021","title":"A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Health and Medical Research Council; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Howard Hughes Medical Institute; Medical Research Council; Siebel Stem Cell Institute; National Institute on Drug Abuse","keywords":"Retrotransposon; Biology; Promoter; Gene isoform; Genetics; Phenotype; Long terminal repeat; Gene; Transposable element; Embryo; Regulation of gene expression; Cell biology; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003349798,0.0007081922,0.0002487437,0.0009601474,0.0004611218,0.000493315,0.0008045956,0.0006673097,0.004067777],"category_scores_gemma":[0.0003007264,0.000501418,0.000348333,0.0003487919,0.0005832384,0.0003685909,0.0004066894,0.001338275,0.00125537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008262128,"about_ca_system_score_gemma":0.0005351971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001165081,"about_ca_topic_score_gemma":0.004553443,"domain_scores_codex":[0.9995579,0.00004998215,0.00004541804,0.0001475507,0.0001100197,0.00008920026],"domain_scores_gemma":[0.9994642,0.0001136402,0.0001522886,0.00007733519,0.0000399407,0.0001526238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006979479,0.00001792005,0.0003109966,0.00001623852,0.000005531164,0.0001325334,0.00001943078,0.00004765059,0.9973238,0.0006756458,0.00008403594,0.001296388],"study_design_scores_gemma":[0.00003793295,0.00008016762,0.003020601,0.00001031266,0.00002902244,0.0008662948,0.00004945932,0.0008702981,0.9882818,0.0001446427,0.006601006,0.000008521466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527891,0.001466432,0.02873882,0.0005701285,0.0003381295,0.0002918179,0.003280281,0.001103553,0.01142158],"genre_scores_gemma":[0.9721944,0.0006097,0.01153939,0.0001946523,0.00003475661,0.00009858047,0.001799356,0.0004196306,0.01310937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004067777,"threshold_uncertainty_score":0.0136081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834111318173277,"score_gpt":0.2559820996827983,"score_spread":0.2276409865010655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}