{"id":"W3205408718","doi":"10.1016/j.cell.2021.09.021","title":"A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Health and Medical Research Council; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Howard Hughes Medical Institute; Medical Research Council; Siebel Stem Cell Institute; National Institute on Drug Abuse","keywords":"Retrotransposon; Biology; Promoter; Gene isoform; Genetics; Phenotype; Long terminal repeat; Gene; Transposable element; Embryo; Regulation of gene expression; Cell biology; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007439038,0.0001172162,0.0002013262,0.00003239032,0.0000823532,0.00002278127,0.00006199543,0.00008605851,0.0001544814],"category_scores_gemma":[0.00008222305,0.0001098802,0.00009201725,0.0000900706,0.00003691925,0.00003072213,0.00002741479,0.0001066516,0.00006024101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004171262,"about_ca_system_score_gemma":0.0002019021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005696532,"about_ca_topic_score_gemma":0.00001610746,"domain_scores_codex":[0.9991437,0.00001206494,0.0002029234,0.0002377694,0.0001519483,0.0002516392],"domain_scores_gemma":[0.9993554,0.0001358833,0.00003909825,0.0002050518,0.0001212949,0.0001432194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00178851,0.001655192,0.0128345,0.00160976,0.0002384097,0.0008038321,0.003402056,0.00003389998,0.9066193,0.001215717,0.05130313,0.01849573],"study_design_scores_gemma":[0.002302459,0.0001143558,0.004184021,0.0001111474,0.00004275842,0.00001818026,0.0001384417,0.0001029046,0.8668254,0.00003891153,0.1259796,0.0001417947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764526,0.001386941,0.01528532,0.0005244597,0.0002017632,0.0003574015,0.00003152389,0.0001125933,0.00564742],"genre_scores_gemma":[0.9623322,0.0001303149,0.03043319,0.0002957571,0.0001609085,0.00004585493,0.0003174659,0.00002711314,0.006257132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07467651,"threshold_uncertainty_score":0.4480785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834111318173277,"score_gpt":0.2559820996827983,"score_spread":0.2276409865010655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}