{"id":"W3205414166","doi":"10.1089/cap.2021.0034","title":"Efficacy and Safety of a Long-Acting Multilayer-Release Methylphenidate Formulation (PRC-063) in the Treatment of Adolescent Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Clinical Trial with a 6-Month Open-Label Extension","year":2021,"lang":"en","type":"article","venue":"Journal of Child and Adolescent Psychopharmacology","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Placebo; Methylphenidate; Attention deficit hyperactivity disorder; Randomized controlled trial; Adverse effect; Psychology; Clinical Global Impression; Clinical endpoint; Clinical trial; Psychiatry; Medicine; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002227515,0.001328162,0.002358753,0.0004642458,0.0004430526,0.0007741502,0.001559905,0.001968584,0.005284383],"category_scores_gemma":[0.00181953,0.0008687439,0.001407079,0.0004011054,0.001249616,0.001126679,0.0005123065,0.002932519,0.00100191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006163736,"about_ca_system_score_gemma":0.0014488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008028104,"about_ca_topic_score_gemma":0.001602097,"domain_scores_codex":[0.9991159,0.0003881233,0.0001093877,0.0001586643,0.0001372602,0.00009074576],"domain_scores_gemma":[0.9984872,0.0003141347,0.0004221189,0.0001478875,0.0001320036,0.0004966042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534966,0.01882623,0.0004977716,0.0005304191,0.0003909795,0.00002528317,0.00005014185,0.0001613765,0.006818265,0.00003700294,0.0002189246,0.018947],"study_design_scores_gemma":[0.8156976,0.1801051,0.002275396,0.00002273958,0.0002601082,0.00003355254,0.00001399937,0.0002568639,0.001059865,0.00002653997,0.000233939,0.00001418181],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932654,0.002157391,0.000435061,0.0001802581,0.0001615692,0.002691084,0.0005298331,0.00008042403,0.0004990026],"genre_scores_gemma":[0.9881864,0.002663824,0.002521395,0.0003889486,0.0003783922,0.003512434,0.00089504,0.00002734131,0.001426272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005284383,"threshold_uncertainty_score":0.01767796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08747277992799993,"score_gpt":0.4272683290930568,"score_spread":0.3397955491650569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}