{"id":"W3205424152","doi":"10.1016/j.jgo.2021.10.002","title":"Immune related adverse events and treatment discontinuation in patients older and younger than 75 years with advanced melanoma receiving nivolumab or pembrolizumab","year":2021,"lang":"en","type":"article","venue":"Journal of Geriatric Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria; University of British Columbia","funders":"AstraZeneca","keywords":"Medicine; Discontinuation; Internal medicine; Nivolumab; Adverse effect; Hazard ratio; Incidence (geometry); Pembrolizumab; Cohort; Proportional hazards model; Logistic regression; Retrospective cohort study; Cancer; Immunotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000629215,0.0001175374,0.0003836339,0.0002709727,0.0003254771,0.0004622179,0.0001187016,0.0002875954,0.001171219],"category_scores_gemma":[0.002884741,0.00008680455,0.0008259392,0.0004417453,0.00009627963,0.0002942583,0.0002160951,0.0007103616,0.00007047362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004051819,"about_ca_system_score_gemma":0.0004053623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002077535,"about_ca_topic_score_gemma":0.004031852,"domain_scores_codex":[0.9996012,0.00009868629,0.00005101597,0.00004961123,0.00009616259,0.0001033758],"domain_scores_gemma":[0.9986531,0.0003361773,0.0007138507,0.00003176057,0.00007262063,0.0001925244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002671933,0.0001427668,0.9745148,0.00009420365,0.0004314459,0.0004350092,0.0001062601,0.0001721946,0.0003565493,0.00004819093,0.0003863517,0.02064019],"study_design_scores_gemma":[0.0001047214,0.0005131234,0.9964947,0.00004946168,0.000268036,0.0008169294,0.00012903,0.0002941558,0.00008289009,0.00007370969,0.001167232,0.000006039081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948816,0.003454692,0.00006687126,0.0001718678,0.00002849084,0.00001325674,0.0001973338,0.000002508226,0.001183404],"genre_scores_gemma":[0.9986249,0.0007021282,0.00004259462,0.0001826436,0.000041753,0.000008815652,0.0001644455,0.000001054091,0.0002316374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002077535,"threshold_uncertainty_score":0.00413084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006622549659378028,"score_gpt":0.259965593579468,"score_spread":0.2533430439200899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}