{"id":"W3205424959","doi":"10.1101/2021.10.17.464700","title":"Plant-based production of SARS-CoV-2 antigens for use in a subunit vaccine","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"","keywords":"Virology; Glycoprotein; Antibody; Protein subunit; Recombinant DNA; Biology; Antigen; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Coronavirus disease 2019 (COVID-19); Receptor; Immunology; Molecular biology; Medicine; Genetics; Gene; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000238369,0.000281866,0.0003541151,0.0001302237,0.00004817865,0.00004691327,0.0002535937,0.0003856057,0.000002192214],"category_scores_gemma":[0.0001165045,0.0003139498,0.0001387573,0.0002116394,0.00003726698,0.000007315017,0.00008939077,0.000202899,9.923908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002961955,"about_ca_system_score_gemma":0.0004782916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008751295,"about_ca_topic_score_gemma":0.0001824777,"domain_scores_codex":[0.9983889,0.00005223758,0.0004089069,0.0007521152,0.0001166612,0.000281155],"domain_scores_gemma":[0.9985162,0.00001909227,0.0002325436,0.0008935044,0.0002882137,0.00005042401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009964747,0.0002162341,0.008130373,0.0002731255,0.00007665384,0.000004017784,0.000002629082,0.0001342004,0.9906753,0.00002712566,0.0003595039,0.000001248428],"study_design_scores_gemma":[0.0005522521,0.00004527926,0.04135572,0.0001731478,0.00005543257,2.219864e-8,0.000001780425,0.0001782849,0.9521289,2.593803e-7,0.005193534,0.0003153366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921345,0.0004474661,0.005005389,0.0001093126,0.00031342,0.0008065092,0.001151705,0.00003118619,5.771761e-7],"genre_scores_gemma":[0.9920744,0.0002588127,0.007027094,0.0000990074,0.0001804405,0.0002679795,0.00003114647,0.00005865256,0.00000246653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03854629,"threshold_uncertainty_score":0.9999313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0304556692403526,"score_gpt":0.2514970026950898,"score_spread":0.2210413334547373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}