{"id":"W3205497581","doi":"10.1016/j.stemcr.2021.09.020","title":"A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Progenitor cell; Induced pluripotent stem cell; Biology; Lung; Stem cell; Bioinformatics; Progenitor; Cancer research; Computational biology; Internal medicine; Medicine; Embryonic stem cell; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617997,0.0006869321,0.0006346593,0.001042239,0.000411201,0.0008823491,0.0009950869,0.0008065181,0.005144477],"category_scores_gemma":[0.001056199,0.0005177324,0.0007834275,0.0003558522,0.000497561,0.0006693329,0.001401861,0.001224896,0.002214802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005580051,"about_ca_system_score_gemma":0.001482309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002363741,"about_ca_topic_score_gemma":0.004944231,"domain_scores_codex":[0.9988481,0.00009771529,0.00006704502,0.0001739102,0.0007382929,0.00007499212],"domain_scores_gemma":[0.9992484,0.0001638935,0.00008721352,0.0001369473,0.0002336721,0.0001297345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212493,0.00009018,0.0006389589,0.00009275327,0.00002940919,0.0002761964,0.00009219794,0.001029549,0.9780475,0.001000968,0.00174454,0.01683649],"study_design_scores_gemma":[0.00007979573,0.0004883445,0.00372542,0.00005219216,0.0001046114,0.001051408,0.00006819324,0.01165339,0.9274158,0.0009891066,0.05430229,0.00006939825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1530415,0.001651963,0.8050452,0.001148215,0.0004787413,0.002224711,0.007341408,0.01207091,0.01699734],"genre_scores_gemma":[0.3356428,0.002408595,0.6230676,0.001036006,0.0001302817,0.00346396,0.01301837,0.001209522,0.02002274],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005144477,"threshold_uncertainty_score":0.01721001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02572172942372277,"score_gpt":0.2798211113893259,"score_spread":0.2540993819656031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}