{"id":"W3205497581","doi":"10.1016/j.stemcr.2021.09.020","title":"A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Progenitor cell; Induced pluripotent stem cell; Biology; Lung; Stem cell; Bioinformatics; Progenitor; Cancer research; Computational biology; Internal medicine; Medicine; Embryonic stem cell; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001854198,0.0003569848,0.0006049887,0.00009036151,0.0001842051,0.0001004775,0.0001059738,0.0001446199,0.000162419],"category_scores_gemma":[0.0004841373,0.0003047513,0.0001882533,0.0003491298,0.00004494854,0.0001685765,0.0000921765,0.0002389255,0.00002837915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012272,"about_ca_system_score_gemma":0.0007400267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002605019,"about_ca_topic_score_gemma":0.00001753181,"domain_scores_codex":[0.9966577,0.00004332335,0.0008014258,0.0009186307,0.0009238055,0.0006551747],"domain_scores_gemma":[0.996681,0.001070686,0.0004334711,0.0008262855,0.0005589919,0.0004295737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001286111,0.0006416445,0.01637191,0.0005340865,0.0001924392,0.001322538,0.0003669656,0.00006628782,0.8798268,0.000005609433,0.007799373,0.0915862],"study_design_scores_gemma":[0.003692203,0.001606894,0.0160911,0.000661394,0.0001036481,0.00005570673,0.0001557818,0.0002587565,0.9682417,0.0004192089,0.008323068,0.0003905146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921637,0.001430678,0.001925666,0.00008356538,0.00107582,0.002236666,0.00009833978,0.0001571942,0.0008283652],"genre_scores_gemma":[0.9331121,0.00004309212,0.06320433,0.0001189393,0.0005801405,0.0001913081,0.0004124522,0.0001056004,0.002232028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09119569,"threshold_uncertainty_score":0.9999405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02572172942372277,"score_gpt":0.2798211113893259,"score_spread":0.2540993819656031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}