{"id":"W3205560312","doi":"10.1016/j.immuni.2021.09.017","title":"25-hydroxycholesterol: Gatekeeper of intestinal IgA","year":2021,"lang":"en","type":"letter","venue":"Immunity","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis","keywords":"Biology; Germinal center; Immune system; Immunity; Cholesterol; Transcription factor; Immunology; Cell biology; B cell; Endocrinology; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003212687,0.000446347,0.001197887,0.0002369396,0.00006765438,0.00003587093,0.0003757369,0.0008074478,0.0007411846],"category_scores_gemma":[0.0002942102,0.0003990523,0.000447077,0.0002872266,0.0002624157,0.00008058726,0.0002634755,0.004366774,0.0001109036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005777076,"about_ca_system_score_gemma":0.0002583507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620235,"about_ca_topic_score_gemma":0.00001096823,"domain_scores_codex":[0.9975976,0.0003005892,0.0006793381,0.0004078938,0.0005655282,0.0004490802],"domain_scores_gemma":[0.9974399,0.000164812,0.0003255765,0.001553223,0.0004005384,0.0001159966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001142271,0.0005093255,0.004114866,0.002135563,0.0005041587,0.001263094,0.0008756234,8.535943e-7,0.01995966,0.00001400622,0.958569,0.01193963],"study_design_scores_gemma":[0.001641214,0.0001715947,0.04114637,0.001736457,0.0005216702,0.0008430579,0.00006471482,0.000005658096,0.003939878,0.00005042195,0.9495363,0.0003427025],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5926657,0.004647668,0.0000643523,0.3804049,0.002961672,0.0007269967,0.0001270444,0.000201395,0.01820025],"genre_scores_gemma":[0.1132878,0.0003142961,0.0008322381,0.850696,0.008715088,0.00005000711,0.002096045,0.0002108357,0.02379767],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4793779,"threshold_uncertainty_score":0.9998462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03350861381030502,"score_gpt":0.2793557287122861,"score_spread":0.2458471149019811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}