{"id":"W3205560312","doi":"10.1016/j.immuni.2021.09.017","title":"25-hydroxycholesterol: Gatekeeper of intestinal IgA","year":2021,"lang":"en","type":"letter","venue":"Immunity","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis","keywords":"Biology; Germinal center; Immune system; Immunity; Cholesterol; Transcription factor; Immunology; Cell biology; B cell; Endocrinology; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001834386,0.0008634305,0.001185292,0.0004381231,0.003654863,0.002810665,0.001098686,0.03969159,0.003190646],"category_scores_gemma":[0.01229036,0.0005540818,0.001002849,0.0002596348,0.002740559,0.002413642,0.001273444,0.03376304,0.002292723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004315587,"about_ca_system_score_gemma":0.002935213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004814203,"about_ca_topic_score_gemma":0.007491114,"domain_scores_codex":[0.998569,0.0005047831,0.0001337407,0.0001925699,0.0003076272,0.0002922542],"domain_scores_gemma":[0.9978688,0.001256098,0.0001246711,0.00009400724,0.0001981191,0.0004584237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002922789,0.00008625786,0.001350876,0.00007005742,0.00004192338,0.01270413,0.0002751035,0.0001393657,0.0006867466,0.01474853,0.9568177,0.01278709],"study_design_scores_gemma":[0.0005262977,0.0002244432,0.002490994,0.0003257194,0.00007763935,0.006999337,0.0006758083,0.001334443,0.001012244,0.05152143,0.9347169,0.00009482654],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0009569108,0.001715469,0.00009829348,0.9764509,0.01752995,0.00001330334,0.00003114112,0.0000200154,0.003183937],"genre_scores_gemma":[0.02471031,0.002431182,0.0003641378,0.8664057,0.09219031,0.00007089587,0.00002918682,0.00002658047,0.01377182],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03969159,"threshold_uncertainty_score":0.03131193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03350861381030502,"score_gpt":0.2793557287122861,"score_spread":0.2458471149019811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}