{"id":"W3205576405","doi":"10.1186/s12935-021-02201-6","title":"Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation","year":2021,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Zhejiang University; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Scutellaria baicalensis; Coptis chinensis; KEGG; Gardenia jasminoides; Cell cycle; MAPK/ERK pathway; Cell growth; PI3K/AKT/mTOR pathway; Traditional medicine; Coptis; Apoptosis; Cancer research; Biology; PTEN; Kinase; Medicine; Traditional Chinese medicine; Transcriptome; Gene; Cell biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005395367,0.0005014048,0.0007506447,0.001170631,0.0004464441,0.0005890519,0.000372024,0.0002369545,0.001903113],"category_scores_gemma":[0.0005099747,0.0001321246,0.001027906,0.0009697996,0.0002901758,0.0006147865,0.0003577251,0.0004456235,0.0001362769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007266288,"about_ca_system_score_gemma":0.001267215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002308095,"about_ca_topic_score_gemma":0.002439388,"domain_scores_codex":[0.9997452,0.00005631407,0.00001669232,0.00007152846,0.00007966816,0.0000306769],"domain_scores_gemma":[0.9998179,0.00006529869,0.00003666336,0.00001462437,0.00004563459,0.00001979215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003776649,0.002113553,0.1137751,0.01572975,0.002819778,0.001430508,0.0005694354,0.04693414,0.3080187,0.01501351,0.01551218,0.4743067],"study_design_scores_gemma":[0.001296223,0.008296355,0.3505918,0.001311683,0.0103763,0.001965246,0.0009710666,0.3271258,0.1897022,0.02867417,0.07937019,0.0003190052],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.888333,0.03875433,0.04608737,0.001755757,0.0002361615,0.000931762,0.01127354,0.0009920163,0.01163614],"genre_scores_gemma":[0.955501,0.01738914,0.01780392,0.0002934587,0.00007084257,0.0007874098,0.006924051,0.00004205802,0.001187979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308095,"threshold_uncertainty_score":0.006366551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240599193965888,"score_gpt":0.4128980436008427,"score_spread":0.3804920516611838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}