{"id":"W3205621787","doi":"10.3390/cancers13205091","title":"The Evolution of Clinically Aggressive Triple-Negative Breast Cancer Shows a Large Mutational Diversity and Early Metastasis to Lymph Nodes","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Universidad Nacional Autónoma de México; Consejo Nacional de Ciencia y Tecnología; World Health Organization","keywords":"Triple-negative breast cancer; PTEN; Breast cancer; Medicine; Metastasis; Lymph; Targeted therapy; Copy-number variation; Lymph node; Exome sequencing; Cancer; Exome; Primary tumor; Cancer research; Oncology; Biology; Pathology; Mutation; Internal medicine; Gene; Genetics; PI3K/AKT/mTOR pathway; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407711,0.00008873406,0.0001274,0.000016996,0.0003083695,0.00001743048,0.0001079557,0.00005669341,0.00002040876],"category_scores_gemma":[0.0003467745,0.00007705535,0.000072813,0.0001020914,0.0001149267,0.000003945821,0.000373896,0.00004256199,6.970232e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003028635,"about_ca_system_score_gemma":0.0009339975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001598009,"about_ca_topic_score_gemma":0.001707692,"domain_scores_codex":[0.9992492,0.0000435853,0.0001819732,0.0002476444,0.0001165268,0.0001610653],"domain_scores_gemma":[0.9991741,0.00009003625,0.0001662128,0.000153665,0.0003276077,0.00008843454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00400656,0.0001503367,0.8351783,0.0001108247,0.001936129,0.00005732406,0.00464398,0.006256268,0.0887187,0.004309747,0.00906436,0.04556748],"study_design_scores_gemma":[0.004812283,0.0003292671,0.9343204,0.000135886,0.0003499888,0.00005060578,0.004593145,0.0003824939,0.04690559,0.001274691,0.006244987,0.000600663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931949,0.003623878,0.0009907362,0.0003029523,0.0002432779,0.0001189529,0.001395393,0.000002482248,0.0001274652],"genre_scores_gemma":[0.9976103,0.001432735,0.0002826996,0.0003094339,0.0001334245,0.00002932845,0.00001592022,0.000007761603,0.0001784357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09914212,"threshold_uncertainty_score":0.3142226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193246165092865,"score_gpt":0.2730427102467367,"score_spread":0.2611102485958081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}