{"id":"W3205644932","doi":"10.1016/j.cjca.2021.07.020","title":"EICOSAPENTAENOIC ACID INHIBITS LIPOPOLYSACCHARIDE (LPS)-INDUCED MACROPHAGE ACTIVATION THROUGH A POTENTIAL CYCLOOXYGENASE PATHWAY","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Eicosapentaenoic acid; Nitric oxide synthase; Nitrite; Nitric oxide; Lipopolysaccharide; Cyclooxygenase; Pharmacology; Medicine; Diclofenac; Macrophage; Inflammation; Biochemistry; Internal medicine; Enzyme; Chemistry; Fatty acid; In vitro; Polyunsaturated fatty acid; Nitrate","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769677,0.0005140905,0.0004259077,0.0003307604,0.0003015162,0.0002806556,0.0002593795,0.0004603432,0.002714095],"category_scores_gemma":[0.0003377308,0.0002024137,0.0004178719,0.0002091035,0.0003683641,0.0002236947,0.0002611061,0.001117557,0.0005612241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172851,"about_ca_system_score_gemma":0.0007147797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237427,"about_ca_topic_score_gemma":0.002274134,"domain_scores_codex":[0.9997961,0.00005660095,0.00002100897,0.00001537468,0.00003571681,0.00007523823],"domain_scores_gemma":[0.9997895,0.00004344798,0.00003091731,0.00002239836,0.00003518445,0.00007856467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01095555,0.001126829,0.0004296042,0.0002133586,0.00004039475,0.0002773892,0.00006680108,0.0001728656,0.977537,0.000229214,0.0002642072,0.008686693],"study_design_scores_gemma":[0.001072712,0.007405481,0.01136884,0.00004937331,0.0000873688,0.0002585615,0.0001233339,0.000856423,0.9755289,0.0001641506,0.003069311,0.00001563832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987106,0.00408406,0.002662182,0.0006450647,0.0003084831,0.0001280482,0.0004247706,0.0001022983,0.004539228],"genre_scores_gemma":[0.9892301,0.002698844,0.002113082,0.0002319746,0.0001310333,0.0001212018,0.0004505202,0.00001751638,0.005005799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002714095,"threshold_uncertainty_score":0.009079576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143588814491676,"score_gpt":0.2411356780584281,"score_spread":0.2267767966092605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}