{"id":"W3205657594","doi":"10.3390/cancers13205145","title":"Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Victorian Cancer Agency","keywords":"Atypical teratoid rhabdoid tumor; Panobinostat; SMARCB1; Cancer research; Neurogenesis; Biology; Histone deacetylase; Chromatin remodeling; Histone; Cell biology; Gene; Genetics; Medulloblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086254,0.000166042,0.0003187316,0.0001825566,0.0001073894,0.0002479479,0.00008980565,0.0002198307,0.001261293],"category_scores_gemma":[0.00011816,0.00009754689,0.0001838614,0.0001377991,0.0001517218,0.0001439471,0.0001583923,0.0003979653,0.0004469174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674178,"about_ca_system_score_gemma":0.0001524824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003002274,"about_ca_topic_score_gemma":0.0006832174,"domain_scores_codex":[0.999923,0.00001129465,0.000007988667,0.00001800542,0.00002354273,0.00001609869],"domain_scores_gemma":[0.9998853,0.00001911028,0.00004090841,0.00001751024,0.00001420211,0.00002298205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002460389,0.00006242899,0.00180943,0.00008811735,0.00001644834,0.0006282164,0.00003712857,0.0002287564,0.9875455,0.0002329267,0.0001157873,0.008989139],"study_design_scores_gemma":[0.00007921218,0.00207429,0.03987426,0.00002863701,0.00007379326,0.01061004,0.0001188634,0.001452047,0.924742,0.0003009081,0.02063271,0.000013164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907017,0.004292191,0.001775403,0.00006994708,0.00001932958,0.00005723742,0.0001835028,0.00007310466,0.002827608],"genre_scores_gemma":[0.9952222,0.002066135,0.00069085,0.00003477986,0.000004541683,0.00002319496,0.0002540022,0.000009304163,0.001695089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261293,"threshold_uncertainty_score":0.004219472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221868125274081,"score_gpt":0.2536423147283979,"score_spread":0.2414236334756571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}