{"id":"W3205657594","doi":"10.3390/cancers13205145","title":"Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Victorian Cancer Agency","keywords":"Atypical teratoid rhabdoid tumor; Panobinostat; SMARCB1; Cancer research; Neurogenesis; Biology; Histone deacetylase; Chromatin remodeling; Histone; Cell biology; Gene; Genetics; Medulloblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004330118,0.0001297674,0.000129125,0.00002249886,0.00006648908,0.00003218255,0.0000966881,0.00009448802,0.0001486952],"category_scores_gemma":[0.00005363105,0.0001254042,0.00007515573,0.000128077,0.00002512532,0.000002651305,0.00003902541,0.00007156042,0.0000246516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640775,"about_ca_system_score_gemma":0.0003890634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002855957,"about_ca_topic_score_gemma":0.0001515101,"domain_scores_codex":[0.999136,0.00004398918,0.0001392376,0.000335258,0.0001217728,0.0002236923],"domain_scores_gemma":[0.9994392,0.000008205029,0.00005046382,0.0002568572,0.0001282052,0.0001170945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424182,0.00001711275,0.004881919,0.00001245469,0.00003403183,0.000005000096,0.000100157,0.00143511,0.9756633,0.000006489854,0.014476,0.003226018],"study_design_scores_gemma":[0.001098017,0.0002360303,0.01452039,0.00005144827,0.00001007964,0.000008398863,0.0003654239,0.0006181285,0.9245278,0.00003424345,0.05819697,0.000333024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957883,0.001630315,0.001368095,0.000439112,0.0003531921,0.0001085521,0.00005231021,0.00002423686,0.0002358996],"genre_scores_gemma":[0.9957075,0.0009224247,0.0002566542,0.001574802,0.0003023037,0.00003483708,0.0002996231,0.00002378461,0.0008780588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05113544,"threshold_uncertainty_score":0.5113835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221868125274081,"score_gpt":0.2536423147283979,"score_spread":0.2414236334756571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}