{"id":"W3205694228","doi":"10.1126/sciadv.abg3947","title":"GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"GLUT4; Medicine; Diabetes mellitus; Internal medicine; Endocrinology; Bioinformatics; Insulin resistance; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113245,0.0001157961,0.0001157493,0.00005900332,0.0001272941,0.00003383357,0.0002670407,0.00005798753,0.00003388542],"category_scores_gemma":[0.0001918583,0.0001117289,0.00003170707,0.0004574591,0.0003237375,0.00003890059,0.0001254277,0.00007327065,0.00001588649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001664252,"about_ca_system_score_gemma":0.0002786353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001277734,"about_ca_topic_score_gemma":0.00006085133,"domain_scores_codex":[0.9989032,0.00001785745,0.0001355015,0.0004270061,0.00014241,0.0003740771],"domain_scores_gemma":[0.9995277,0.00002229702,0.0000362462,0.0002485408,0.00006868666,0.00009654865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005588067,0.00002280188,0.000588546,0.00001066933,0.000003053384,0.000003711831,0.000105193,0.0008818169,0.981523,0.0002497141,0.00001049588,0.01654511],"study_design_scores_gemma":[0.0006155728,0.0001357753,0.008028403,0.00003929427,0.000004019262,0.00001144206,0.0006830559,0.00007338406,0.9809117,0.001753961,0.007506006,0.0002373954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944504,0.002103203,0.000283985,0.0001129687,0.0002114012,0.00008949808,0.000005458528,0.000009921397,0.002733196],"genre_scores_gemma":[0.9974217,0.00009445465,0.001370383,0.00097051,0.00003441411,0.0000150526,0.000009857633,0.000006745638,0.00007691451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01630771,"threshold_uncertainty_score":0.4556172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610274124001707,"score_gpt":0.2662313339661668,"score_spread":0.258621059842165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}