{"id":"W3205755504","doi":"10.1002/mabi.202100292","title":"Immune Response to Silk Sericin–Fibroin Composites: Potential Immunogenic Elements and Alternatives for Immunomodulation","year":2021,"lang":"en","type":"review","venue":"Macromolecular Bioscience","topic":"Silk-based biomaterials and applications","field":"Materials Science","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Natural Science Foundation of China","keywords":"Fibroin; Sericin; SILK; Immunogenicity; Immune system; Materials science; Tissue engineering; Composite number; Coating; Composite material; Chemistry; Immunology; Biomedical engineering; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001685641,0.0005250549,0.001055007,0.0002409199,0.0005780328,0.0006986074,0.0009614316,0.0001461421,0.00007649876],"category_scores_gemma":[0.0001631009,0.0004687797,0.0003513424,0.0006810933,0.000240005,0.0001521623,0.0006064369,0.00008597394,0.00009863197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477933,"about_ca_system_score_gemma":0.0002538532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005744287,"about_ca_topic_score_gemma":0.000001054551,"domain_scores_codex":[0.9961204,0.00066091,0.0009994237,0.00119596,0.0004276825,0.000595659],"domain_scores_gemma":[0.9981126,0.0001429537,0.0005464058,0.0008585313,0.0001698349,0.0001696769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005544345,0.00006345505,3.114892e-7,0.0006205301,0.00002722178,0.00001810042,0.00004561403,0.000009300876,0.9537675,0.00006105239,0.00001803635,0.04531346],"study_design_scores_gemma":[0.001125973,0.0008007938,0.0002587512,0.007403581,0.0006528306,0.0004008118,0.00008565078,0.0002809908,0.5777677,0.00009092964,0.409189,0.001943041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1156307,0.8628433,0.01765411,0.0001210321,0.0006038652,0.002215947,0.0008320896,0.00008815335,0.00001081291],"genre_scores_gemma":[0.05130314,0.8957288,0.04949707,0.0002906238,0.0002773631,0.001367878,0.001050282,0.0002163756,0.000268473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.409171,"threshold_uncertainty_score":0.9997764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042872200244629,"score_gpt":0.3211553905767847,"score_spread":0.3007266685743384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}