{"id":"W3205789862","doi":"10.1002/cam4.4331","title":"Interleukin‐33 as an early predictor of cetuximab treatment efficacy in patients with colorectal cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Cetuximab; Medicine; Colorectal cancer; Peripheral blood mononuclear cell; CD8; Flow cytometry; Interleukin 12; IL-2 receptor; Internal medicine; Interleukin; Immune system; Cancer research; Oncology; Immunology; Cancer; T cell; Cytotoxic T cell; Cytokine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002882993,0.0002269271,0.0002841509,0.0003148207,0.0001539399,0.0002661361,0.00009600917,0.000283382,0.0009926354],"category_scores_gemma":[0.0006454985,0.0001023786,0.0002747751,0.0002047912,0.0001224926,0.0001775116,0.0002024037,0.0004707178,0.0001169499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329308,"about_ca_system_score_gemma":0.0001900288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003713394,"about_ca_topic_score_gemma":0.00068736,"domain_scores_codex":[0.9998628,0.00003803315,0.00001747428,0.00002470485,0.00002575568,0.00003114925],"domain_scores_gemma":[0.9995085,0.00008421336,0.0002083816,0.00001537903,0.00005909648,0.0001243516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00442082,0.000190386,0.9741136,0.00009974564,0.0001023533,0.0002878155,0.00006038426,0.0002359222,0.009177173,0.00004478271,0.0003528899,0.01091406],"study_design_scores_gemma":[0.0001021886,0.001399954,0.9923199,0.00002547525,0.0002041182,0.0007046909,0.00008709284,0.001335546,0.00272201,0.00008460775,0.001003259,0.00001117762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972166,0.001956939,0.0001947573,0.00008131882,0.00001634937,0.00002064278,0.0001434981,0.000007232311,0.0003626369],"genre_scores_gemma":[0.9993191,0.0001698009,0.0001485316,0.0000296077,0.00001151615,0.00001344363,0.0001322689,8.013213e-7,0.0001750384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009926354,"threshold_uncertainty_score":0.003320694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090367829385499,"score_gpt":0.2580020021448146,"score_spread":0.2470983238509596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}