{"id":"W3205797556","doi":"10.1093/brain/awab382","title":"A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Occupational Cancer Research Centre; Health Sciences Centre; Montreal Neurological Institute and Hospital; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"Demensfonden; Stichting Dioraphte; Vetenskapsrådet; Stockholms Läns Landsting; Hartstichting; Brain Research UK; Deutsche Forschungsgemeinschaft; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Karolinska Institutet; Institute on the Environment, University of Minnesota; European Commission; Wellcome Trust; National Institute for Health and Care Research; Medical Research Council; Biogen; ZonMw; Alzheimer's Association","keywords":"Frontotemporal dementia; Biomarker; Dementia; C9orf72; Medicine; Oncology; Cohort; Pathology; Disease; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006099744,0.001448018,0.001724728,0.001216071,0.0005158942,0.001567131,0.00195119,0.002075855,0.002545876],"category_scores_gemma":[0.01302563,0.001276867,0.001622276,0.0006215732,0.001342341,0.001036702,0.001391755,0.002161934,0.0005408806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001642867,"about_ca_system_score_gemma":0.001257913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03031488,"about_ca_topic_score_gemma":0.01418034,"domain_scores_codex":[0.9986874,0.000630371,0.00006500335,0.0003529703,0.00008261866,0.0001816334],"domain_scores_gemma":[0.9920954,0.005954669,0.0008341255,0.0002446987,0.0005529738,0.0003181418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005649304,0.0001271281,0.02243513,0.00007832473,0.0002377078,0.0003325966,0.0002703547,0.9604688,0.0007954607,0.007081904,0.0006018636,0.007005664],"study_design_scores_gemma":[0.00004883935,0.00007030398,0.002508399,0.00001379077,0.0000387482,0.00005248344,0.00001990429,0.9932652,0.00009648976,0.003696565,0.0001718448,0.00001741645],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7862684,0.00110058,0.2040955,0.002502884,0.0001025532,0.0002378238,0.002507395,0.0005068994,0.002678032],"genre_scores_gemma":[0.9834373,0.0002670377,0.009980338,0.0001836138,0.00002968603,0.0002498104,0.001145644,0.00003497188,0.004671721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03031488,"threshold_uncertainty_score":0.06027681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07419094837245015,"score_gpt":0.3548926304521308,"score_spread":0.2807016820796807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}