{"id":"W3205797556","doi":"10.1093/brain/awab382","title":"A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Occupational Cancer Research Centre; Health Sciences Centre; Montreal Neurological Institute and Hospital; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"Demensfonden; Stichting Dioraphte; Vetenskapsrådet; Stockholms Läns Landsting; Hartstichting; Brain Research UK; Deutsche Forschungsgemeinschaft; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Karolinska Institutet; Institute on the Environment, University of Minnesota; European Commission; Wellcome Trust; National Institute for Health and Care Research; Medical Research Council; Biogen; ZonMw; Alzheimer's Association","keywords":"Frontotemporal dementia; Biomarker; Dementia; C9orf72; Medicine; Oncology; Cohort; Pathology; Disease; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039848,0.00009645225,0.000205865,0.00007880498,0.00002188137,0.00001178233,0.0001942081,0.00005265254,0.0002116608],"category_scores_gemma":[0.0002493197,0.00008031313,0.00004642302,0.0002062301,0.00007792799,0.00008972645,0.000365819,0.0000971587,0.00001158757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005225967,"about_ca_system_score_gemma":0.0004379706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006641071,"about_ca_topic_score_gemma":0.00007848902,"domain_scores_codex":[0.9985685,0.0001138528,0.0002819459,0.0003579679,0.0004270664,0.000250625],"domain_scores_gemma":[0.9989501,0.00002786718,0.00004667915,0.0006893454,0.00006590418,0.0002201097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001198324,0.0009264685,0.5734454,0.0004658052,0.0003445824,0.0008270406,0.0002213581,0.001104044,0.3690525,0.00005187145,0.020829,0.03153355],"study_design_scores_gemma":[0.001757397,0.00006042479,0.5892092,0.0003149176,0.00004828913,0.000003782966,0.0000197293,0.4075733,0.0003832877,0.0001298092,0.0004088366,0.00009103058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914852,0.001756656,0.0009408051,0.005046254,0.00002645826,0.0004087799,0.0001199847,0.00001982917,0.0001959965],"genre_scores_gemma":[0.9845706,0.00006920449,0.01452043,0.0002011576,0.00003416346,0.00002208678,0.0003365684,0.00001910396,0.0002267324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4064692,"threshold_uncertainty_score":0.3275074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07419094837245015,"score_gpt":0.3548926304521308,"score_spread":0.2807016820796807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}