{"id":"W3206000828","doi":"10.1038/s41467-021-26354-0","title":"COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Amsterdam University Medical Centers; National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Medicine; Monoclonal antibody; Antibody; Respiratory system; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vivo; Neutralizing antibody; Coronavirus disease 2019 (COVID-19); Immunology; Virology; Lung; Pharmacology; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003132265,0.0007639742,0.0006135391,0.0004455763,0.0001936003,0.0003538755,0.0003480314,0.0004719135,0.0009635309],"category_scores_gemma":[0.0001621518,0.0001536437,0.0005771695,0.0001173259,0.0002753424,0.0002459213,0.0001564811,0.0008560042,0.0001988721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006004379,"about_ca_system_score_gemma":0.0004323283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132885,"about_ca_topic_score_gemma":0.001686129,"domain_scores_codex":[0.9998778,0.00002034744,0.000007176435,0.00002147393,0.00003581804,0.00003733922],"domain_scores_gemma":[0.9998454,0.00002563491,0.00005434441,0.00001692712,0.00002048987,0.00003715263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008678957,0.0009667825,0.0008134016,0.0001321539,0.00004474952,0.00007433476,0.000022602,0.004980352,0.9833887,0.0006078319,0.0003367041,0.007764465],"study_design_scores_gemma":[0.0002106869,0.01388269,0.004278161,0.00002654056,0.000119991,0.0002406692,0.00003166408,0.02249627,0.9553952,0.0003916514,0.002906577,0.00001979455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866333,0.002501064,0.007466653,0.0002796403,0.00007929218,0.00008892083,0.000460812,0.0002082427,0.002282054],"genre_scores_gemma":[0.9901968,0.001995136,0.003758644,0.0000712153,0.00002538901,0.0001133615,0.0006363369,0.00002077415,0.00318226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132885,"threshold_uncertainty_score":0.004356563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1797442923792143,"score_gpt":0.466285376533132,"score_spread":0.2865410841539178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}