{"id":"W3206004541","doi":"10.1038/s42003-021-02714-w","title":"Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Canadian Glycomics Network; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Epitope; Lipoarabinomannan; Monoclonal antibody; Mycobacterium tuberculosis; Tuberculosis; Virology; Glycan; Antibody; Immunology; Biology; Microbiology; Medicine; Glycoprotein; Molecular biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003028351,0.0004983563,0.0002121166,0.0002671788,0.0002379933,0.0003035803,0.0002223101,0.0008360294,0.003315757],"category_scores_gemma":[0.0003638456,0.0001597432,0.000224389,0.0001280642,0.0002500174,0.0001849529,0.0003169747,0.0007301958,0.000835421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933311,"about_ca_system_score_gemma":0.0001066071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002345577,"about_ca_topic_score_gemma":0.0001989868,"domain_scores_codex":[0.9998094,0.00004657875,0.00001107498,0.00004862334,0.00003650281,0.00004782624],"domain_scores_gemma":[0.9998924,0.00003508553,0.00001666665,0.00001749367,0.00001626973,0.00002221146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005560915,0.0005284383,0.02845001,0.0001982989,0.00006594099,0.001344373,0.0004104495,0.00007718294,0.9192666,0.0008136175,0.002167781,0.04612113],"study_design_scores_gemma":[0.0005665366,0.009598493,0.3075207,0.0002752222,0.0003780341,0.02739908,0.0004967653,0.001216051,0.5216287,0.001883277,0.128985,0.00005217574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804574,0.003516232,0.004451369,0.0006952283,0.0001494594,0.0001766091,0.0002750757,0.000158323,0.01012029],"genre_scores_gemma":[0.9912909,0.001426258,0.002512251,0.0006145167,0.000112916,0.0000937072,0.0005843748,0.0000155466,0.00334945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003315757,"threshold_uncertainty_score":0.01109231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545135066968257,"score_gpt":0.2741762951702937,"score_spread":0.2387249445006112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}