{"id":"W3206004718","doi":"10.1242/dev.194613","title":"Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Research Organization of Information and Systems","keywords":"Mesoderm; Biology; Somite; Enhancer; Cell biology; FGF and mesoderm formation; Intermediate mesoderm; Embryo; Genetics; Gastrulation; Embryogenesis; Embryonic stem cell; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009954481,0.001160005,0.000361986,0.0009747912,0.0005048005,0.0004776357,0.00116214,0.0008631476,0.003066533],"category_scores_gemma":[0.0006092022,0.0009107809,0.0006048437,0.0004220701,0.0008080293,0.000560234,0.001025937,0.001516126,0.001087314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004079702,"about_ca_system_score_gemma":0.0006026329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005019514,"about_ca_topic_score_gemma":0.0008096213,"domain_scores_codex":[0.9989766,0.0001601547,0.0001433173,0.0002593629,0.0003383534,0.0001223855],"domain_scores_gemma":[0.9989838,0.0002455669,0.0002924341,0.0001656303,0.00008941518,0.0002230853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007764429,0.00002989055,0.0001245954,0.00005336072,0.000005517239,0.0001674176,0.00002713446,0.00008313762,0.9967482,0.00171714,0.00006400565,0.0009019884],"study_design_scores_gemma":[0.00009311277,0.000284011,0.003688407,0.00002421451,0.00003000096,0.001137224,0.00003152397,0.001011473,0.9812111,0.0004279051,0.01204724,0.00001393108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7970073,0.004956329,0.1771194,0.0009423929,0.0001911529,0.000787952,0.005414973,0.0007141604,0.01286639],"genre_scores_gemma":[0.8980947,0.003723906,0.07646977,0.0003452964,0.0001048077,0.001063936,0.004922433,0.0005909627,0.01468418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003066533,"threshold_uncertainty_score":0.01025862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533301210630896,"score_gpt":0.2426105036876016,"score_spread":0.2272774915812927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}