{"id":"W3206007153","doi":"10.1158/2159-8290.cd-21-0506","title":"Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis","year":2021,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Molecular mimicry; Epigenetics; Cancer; Mimicry; Histone; Immune system; Immunology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000339148,0.0005325561,0.0006943789,0.001211035,0.0001716606,0.0006314345,0.000505977,0.0007889324,0.002336348],"category_scores_gemma":[0.0003607431,0.0001762537,0.0002674986,0.001174612,0.0004228425,0.0008154223,0.00044242,0.001490539,0.001311294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000607673,"about_ca_system_score_gemma":0.0006916694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006260826,"about_ca_topic_score_gemma":0.001214766,"domain_scores_codex":[0.9998955,0.00002086318,0.00001301028,0.0000166312,0.00004267884,0.00001131713],"domain_scores_gemma":[0.9998535,0.00007351617,0.00001854803,0.000005528192,0.00003471969,0.00001413573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007353493,0.00005608698,0.0001350846,0.01000437,0.00006605108,0.0002041992,0.00005907267,0.000528325,0.006063255,0.009619233,0.02181385,0.951377],"study_design_scores_gemma":[0.00001183253,0.00007009675,0.0005287844,0.001539258,0.0000483022,0.001143323,0.00003704719,0.0001006575,0.00111347,0.002943645,0.9924515,0.00001204467],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001230281,0.9980218,0.0002003983,0.0002098322,0.0001477482,0.000003046197,0.0000101281,0.000008104234,0.001275806],"genre_scores_gemma":[0.001071033,0.997505,0.0002270599,0.0001939616,0.0001077648,0.000006411875,0.00002428055,0.000001834522,0.0008625916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002336348,"threshold_uncertainty_score":0.007815897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03439607338499383,"score_gpt":0.3369066096164206,"score_spread":0.3025105362314268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}