{"id":"W3206015730","doi":"10.3389/fpsyt.2021.730987","title":"Phenotypic Trade-Offs: Deciphering the Impact of Neurodiversity on Drug Development in Fragile X Syndrome","year":2021,"lang":"en","type":"article","venue":"Frontiers in Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fragile X syndrome; Intellectual disability; Autism; Autism spectrum disorder; FMR1; Clinical trial; Population; Psychology; Anxiety; Cognition; Clinical study design; Neuroscience; Clinical psychology; Medicine; Developmental psychology; Psychiatry; Fragile x; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004475169,0.0004835943,0.001205896,0.0006331149,0.0002390198,0.001524251,0.0005373804,0.0007167517,0.002537348],"category_scores_gemma":[0.008512232,0.0002980002,0.0007102059,0.0003966578,0.00108385,0.001739807,0.0007593673,0.001699806,0.0002952331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007237211,"about_ca_system_score_gemma":0.0006762298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004248686,"about_ca_topic_score_gemma":0.001048187,"domain_scores_codex":[0.9986084,0.0007083641,0.00008838037,0.0001906303,0.0003054031,0.0000989515],"domain_scores_gemma":[0.9962171,0.001941923,0.0009824632,0.0003434528,0.0002799504,0.0002352016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01430171,0.002120486,0.07858258,0.003442131,0.002116516,0.001184134,0.0005250573,0.01269813,0.2292277,0.01789294,0.004790595,0.6331181],"study_design_scores_gemma":[0.001708621,0.05183341,0.5244597,0.001529958,0.006684724,0.006798563,0.001488203,0.07322918,0.1664524,0.08344712,0.08189909,0.0004691464],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9012788,0.06047225,0.02116583,0.004749124,0.0002383055,0.0002704482,0.001339938,0.0002667738,0.01021861],"genre_scores_gemma":[0.9759494,0.01353953,0.007103148,0.001387238,0.0001478803,0.0001940833,0.0004528311,0.00008788306,0.001138057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004475169,"threshold_uncertainty_score":0.02366722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005900480615450617,"score_gpt":0.2181566047044069,"score_spread":0.2122561240889563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}