{"id":"W3206048415","doi":"10.15252/msb.202110335","title":"High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing","year":2021,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Genome editing; Microbiome; Cas9; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002049659,0.0002728619,0.0003907952,0.00008186277,0.00004981408,0.00002437659,0.0002565271,0.0003586168,0.00001148299],"category_scores_gemma":[0.000123411,0.0002807612,0.0001479489,0.0002110955,0.00008746115,0.000003066958,0.0001829089,0.0001142572,0.000005945563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002120666,"about_ca_system_score_gemma":0.00009483186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005856502,"about_ca_topic_score_gemma":0.000006600937,"domain_scores_codex":[0.9982724,0.0001358931,0.0005041157,0.0005441571,0.00009935124,0.0004440921],"domain_scores_gemma":[0.99895,0.00001995862,0.0001383829,0.0005290424,0.0002666335,0.00009600729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001296834,0.00007539642,0.0001347682,0.0001731815,0.0001138087,0.00002048802,0.00002789941,0.003249933,0.9939869,0.0001915982,0.001702496,0.0003105514],"study_design_scores_gemma":[0.0004582626,0.0002339074,0.00002273806,0.00005512708,0.00003786599,0.0001018316,0.00009958201,0.0004124332,0.9829604,0.000007763527,0.0153325,0.0002776078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7578971,0.02201097,0.2182705,0.00005360505,0.001092303,0.0002852572,0.0002136129,0.00003128605,0.0001453048],"genre_scores_gemma":[0.9966215,0.0002060578,0.001829508,0.00004576211,0.0002164725,0.00002412449,0.0006952492,0.0000450915,0.000316251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2387244,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003842842298421581,"score_gpt":0.2490996015674397,"score_spread":0.2452567592690181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}