{"id":"W3206048489","doi":"10.1128/aac.01304-21","title":"<i>In Vitro</i> Activity of Ceftibuten/VNRX-5236 against Urinary Tract Infection Isolates of Antimicrobial-Resistant <i>Enterobacterales</i>","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services","keywords":"Urinary system; Potency; Serine; Drug resistance; In vitro; Minimum inhibitory concentration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002811497,0.0003636882,0.0003076439,0.000224912,0.0001062417,0.0002872402,0.0001988251,0.0001932487,0.001071268],"category_scores_gemma":[0.0003094433,0.0001115371,0.0003079779,0.0003072799,0.0001219907,0.0001481744,0.0001459522,0.0003005229,0.0003260992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198548,"about_ca_system_score_gemma":0.0002587381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003990487,"about_ca_topic_score_gemma":0.003767437,"domain_scores_codex":[0.9996368,0.0001187988,0.0000546861,0.00005373297,0.00006717543,0.00006882665],"domain_scores_gemma":[0.9998281,0.00004190485,0.00003753039,0.00002141144,0.00004608466,0.00002488887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007704336,0.0001737135,0.002123632,0.00009726036,0.0000327544,0.00006934008,0.00002868903,0.0004120905,0.9921216,0.00003898587,0.0002710425,0.003860527],"study_design_scores_gemma":[0.00002465998,0.002170534,0.01253717,0.00001444489,0.00004245538,0.000265618,0.00004103743,0.0004459874,0.9829285,0.0000114154,0.001512054,0.000006099251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919848,0.002372287,0.0008039318,0.0001070153,0.000034236,0.00005150159,0.002228076,0.00004249438,0.002375592],"genre_scores_gemma":[0.9869332,0.001313263,0.002847062,0.00007956,0.0000220931,0.00002983244,0.006064867,0.00001796029,0.002692174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003990487,"threshold_uncertainty_score":0.00793457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007188112078072519,"score_gpt":0.2364786323159344,"score_spread":0.2292905202378618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}