{"id":"W3206160446","doi":"10.1093/cvr/cvab326","title":"Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction","year":2021,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institutes of Health; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; National Heart, Lung, and Blood Institute; Sonnenfeld Stiftung","keywords":"Hypoxic pulmonary vasoconstriction; Purinergic receptor; Hypoxia (environmental); Vasoconstriction; Pannexin; Biology; P2Y receptor; Cell biology; Receptor; Vascular smooth muscle; Internal medicine; Pulmonary hypertension; Endocrinology; Pharmacology; Chemistry; Intracellular; Extracellular; Medicine; Gap junction; Biochemistry; Connexin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769451,0.0003033341,0.0002885833,0.0001097394,0.0001648368,0.0004245941,0.0002395537,0.0005257622,0.001293354],"category_scores_gemma":[0.0001083799,0.00008515319,0.0001624697,0.00009620804,0.0002499626,0.0005870529,0.0002478782,0.0005824379,0.0002056263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316967,"about_ca_system_score_gemma":0.0001559593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007018978,"about_ca_topic_score_gemma":0.0001215356,"domain_scores_codex":[0.999927,0.000009479779,0.000004965692,0.00002785425,0.00001362671,0.00001706014],"domain_scores_gemma":[0.9999316,0.000008219318,0.00002838512,0.000003560891,0.000006776202,0.00002146213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003610624,0.00004305171,0.001739926,0.0002281729,0.00001485601,0.0008215095,0.00004069102,0.0001814854,0.9866223,0.0008387343,0.0004589584,0.008649234],"study_design_scores_gemma":[0.0002584262,0.002108677,0.07956459,0.0001157924,0.0001832305,0.01172547,0.000346089,0.00620926,0.830704,0.001667983,0.06708017,0.00003635779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396721,0.04650459,0.006512919,0.001857811,0.0002429079,0.00006884615,0.0003563905,0.0002712163,0.004513358],"genre_scores_gemma":[0.9836286,0.009512157,0.002019912,0.0003514179,0.0001391872,0.00003960166,0.0004323052,0.0000123197,0.003864517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293354,"threshold_uncertainty_score":0.004326701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04927609119894849,"score_gpt":0.3172428886530839,"score_spread":0.2679667974541354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}