{"id":"W3206160446","doi":"10.1093/cvr/cvab326","title":"Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction","year":2021,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institutes of Health; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; National Heart, Lung, and Blood Institute; Sonnenfeld Stiftung","keywords":"Hypoxic pulmonary vasoconstriction; Purinergic receptor; Hypoxia (environmental); Vasoconstriction; Pannexin; Biology; P2Y receptor; Cell biology; Receptor; Vascular smooth muscle; Internal medicine; Pulmonary hypertension; Endocrinology; Pharmacology; Chemistry; Intracellular; Extracellular; Medicine; Gap junction; Biochemistry; Connexin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107628,0.0001190614,0.000255207,0.0001021707,0.0001150325,0.0000214046,0.000205594,0.0001841468,0.0000352443],"category_scores_gemma":[0.0001326123,0.0001207399,0.0006163201,0.0005086631,0.0001467235,0.000005336392,0.0002798577,0.0002034395,0.00001228975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002224564,"about_ca_system_score_gemma":0.0002803997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002663799,"about_ca_topic_score_gemma":3.856803e-7,"domain_scores_codex":[0.9981007,0.0002631722,0.0002106815,0.0004614743,0.0006179695,0.0003459984],"domain_scores_gemma":[0.9983316,0.0000288386,0.00003102581,0.00085567,0.0006515834,0.0001012977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004306207,0.0001143091,0.0006079914,0.00005006271,0.002753769,0.0001585057,0.00001914149,0.0003673999,0.9882639,0.0002079995,0.003370003,0.00404383],"study_design_scores_gemma":[0.0006415083,0.0001076483,0.001610615,0.00003540972,0.0002149468,0.0005772983,0.0001779376,0.0001160747,0.8965163,0.0000862563,0.09971871,0.0001973099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9153833,0.06558217,0.01222707,0.0001384286,0.0001876333,0.0003242144,0.00004931582,0.00001968653,0.006088131],"genre_scores_gemma":[0.9954906,0.00150741,0.0007722765,0.0000202255,0.000462007,0.00003471703,0.0001469286,0.00002945026,0.001536429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09634871,"threshold_uncertainty_score":0.4923631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04927609119894849,"score_gpt":0.3172428886530839,"score_spread":0.2679667974541354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}