{"id":"W3206160743","doi":"10.1016/j.celrep.2021.109817","title":"Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Centre for Advancing Health Outcomes; Pancreas Centre (Canada); University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"BC Cancer Foundation; Institute of Development and Economic Alternatives; University of Alberta; Neuroendocrine Tumor Research Foundation; American Association for Cancer Research","keywords":"Biology; PDX1; Transcriptome; Stromal cell; Computational biology; Cancer research; Mesenchymal stem cell; Bioinformatics; Genetics; Gene; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005005314,0.000106012,0.0002540014,0.00007860157,0.00003181641,0.00001495849,0.00002405068,0.000005339867,0.00007792244],"category_scores_gemma":[0.000189269,0.00009934629,0.00004466888,0.0002035306,0.00006873447,0.000110658,0.00002808575,0.0001277359,0.000003170181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001789706,"about_ca_system_score_gemma":0.0001462268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006475826,"about_ca_topic_score_gemma":0.000001682516,"domain_scores_codex":[0.9987808,0.00004900569,0.000384931,0.0003294802,0.0002660672,0.000189682],"domain_scores_gemma":[0.9991099,0.0000281679,0.0001881443,0.0003746782,0.0001724544,0.0001266688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005015106,0.0001182984,0.04945365,0.0004474499,0.000008473955,0.01049303,0.00001758529,3.861756e-7,0.9384528,0.00001913197,0.00002758986,0.0009113942],"study_design_scores_gemma":[0.0003777383,0.0001394267,0.1691028,0.00006067941,0.00004786659,0.01446264,0.00002870225,0.00009559256,0.8115817,0.0000604388,0.00397977,0.0000627016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965456,0.0001806322,0.00006750665,0.0006695591,0.0001074359,0.0005251869,0.000003014507,0.0000414637,0.001859676],"genre_scores_gemma":[0.9951292,0.0004844698,0.0003476842,0.00007962171,0.00003403625,0.00004309227,0.00009247367,0.00002311424,0.003766268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1268712,"threshold_uncertainty_score":0.4051224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934524649968558,"score_gpt":0.2753284828147285,"score_spread":0.2559832363150429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}