{"id":"W3206162646","doi":"10.1016/j.omtn.2021.10.016","title":"Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute for Frontier Life and Medical Sciences, Kyoto University; Kyoto University; Canadian Internet Registration Authority; Japan Agency for Medical Research and Development; Gladstone Institutes","keywords":"Proteases; Cathepsin B; TMPRSS2; Biology; Virology; Basigin; Coronavirus; Cathepsin L; Receptor; Cathepsin; Infectivity; Molecular biology; Virus; Enzyme; Coronavirus disease 2019 (COVID-19); Medicine; Biochemistry; Disease; Internal medicine; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126552,0.0001866182,0.0003310772,0.0002284831,0.00004187076,0.00002753198,0.00005033978,0.0001833725,0.00001609694],"category_scores_gemma":[0.00005031784,0.0001822568,0.0001218559,0.0005148185,0.00011072,0.00009380513,0.00006897467,0.0002790879,0.00002066722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009355756,"about_ca_system_score_gemma":0.0001645291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889466,"about_ca_topic_score_gemma":0.00004562256,"domain_scores_codex":[0.9984258,0.0001856656,0.0003226174,0.000374718,0.0004051165,0.000286033],"domain_scores_gemma":[0.999381,0.00002918096,0.00007384382,0.0003602637,0.0001267281,0.00002897069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002598005,0.0004355794,0.02565797,0.00009053051,0.00006797915,0.0003521792,0.0005515635,6.352121e-7,0.9640061,0.00007471001,0.00005019388,0.00845278],"study_design_scores_gemma":[0.003030159,0.0003891827,0.01717739,0.0001366664,0.0000214302,0.00007282481,0.00004507898,0.00007264133,0.9710032,0.0005003096,0.007400597,0.0001504588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971188,0.001020271,0.0004010236,0.0001852855,0.00008370692,0.0004060085,0.000005393252,0.00003617597,0.0007433356],"genre_scores_gemma":[0.9911933,0.0001439393,0.0002561046,0.00826326,0.00004310414,0.00002714486,0.00001018286,0.00004348221,0.00001950417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008480581,"threshold_uncertainty_score":0.7432216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748665601549693,"score_gpt":0.3172958274876715,"score_spread":0.2898091714721746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}