{"id":"W3206169970","doi":"10.1136/bmjopen-2021-049595","title":"Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): trial protocol","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; National Institute for Health and Care Research; Department of Health and Social Care; Juvenile Diabetes Research Foundation United Kingdom","keywords":"Medicine; Ustekinumab; Placebo; Clinical trial; Randomization; Internal medicine; Type 1 diabetes; Type 2 diabetes; Diabetes mellitus; Disease; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005567892,0.004903062,0.00612429,0.0006857282,0.00128711,0.00204176,0.002408169,0.004282765,0.03499187],"category_scores_gemma":[0.004693971,0.001750899,0.002027241,0.0009009148,0.002195948,0.001842562,0.0009784494,0.004409377,0.005991807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001649796,"about_ca_system_score_gemma":0.005347223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345862,"about_ca_topic_score_gemma":0.003423174,"domain_scores_codex":[0.9974009,0.001463925,0.0001399306,0.000328967,0.0002022108,0.0004641107],"domain_scores_gemma":[0.9976857,0.0004921812,0.00061913,0.0002361203,0.0002357043,0.00073116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.980735,0.006627557,0.0003496396,0.001420687,0.0004446649,0.00004529138,0.0000514325,0.0003861446,0.001055475,0.0002372861,0.002738824,0.005907978],"study_design_scores_gemma":[0.9839069,0.01393155,0.0004139256,0.00005071605,0.0001252159,0.00001446938,0.000009569178,0.000201866,0.0001102003,0.000143811,0.001082357,0.000009264953],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2492777,0.005484337,0.004996828,0.00286479,0.00211742,0.7141362,0.0117342,0.0008528586,0.008535609],"genre_scores_gemma":[0.2363867,0.003603242,0.007030048,0.003915353,0.0008490339,0.7330976,0.003947048,0.00007788696,0.01109315],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03499187,"threshold_uncertainty_score":0.1170594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04474182798847852,"score_gpt":0.3770933183550466,"score_spread":0.3323514903665681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}