{"id":"W3206174963","doi":"10.1016/j.celrep.2021.109929","title":"Stabilized coronavirus spike stem elicits a broadly protective antibody","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Defense Advanced Research Projects Agency; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Energy","keywords":"Coronavirus; Spike Protein; Spike (software development); Coronavirus disease 2019 (COVID-19); Antibody; Biology; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Stem cell; Cell biology; Medicine; Genetics; Outbreak; Computer science; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000480251,0.0002259389,0.0004842137,0.0001077098,0.0001021074,0.00005217015,0.00007980088,0.0001660977,0.0001088132],"category_scores_gemma":[0.0003874092,0.0002000569,0.0001968522,0.0004913568,0.00009391181,0.00008354098,0.000142014,0.0004299904,0.0001218072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082772,"about_ca_system_score_gemma":0.001353126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002336287,"about_ca_topic_score_gemma":0.00003340757,"domain_scores_codex":[0.9973673,0.0001024973,0.0005272775,0.0007364898,0.0007705992,0.0004958264],"domain_scores_gemma":[0.9981018,0.0001044935,0.0001900184,0.0009248721,0.00057273,0.0001060704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002443549,0.0004354696,0.06094181,0.0002993653,0.00005676658,0.02570817,0.000365557,3.457164e-7,0.9042369,0.00001123321,0.0002324597,0.007467618],"study_design_scores_gemma":[0.00110755,0.0002347717,0.009833994,0.0001145395,0.00005574304,0.001910182,0.0003534858,0.00003465603,0.8282318,0.000147345,0.1577796,0.0001963839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601279,0.001682262,0.000268255,0.0001071339,0.0002888745,0.001136547,0.000003493502,0.0001379493,0.03624752],"genre_scores_gemma":[0.9924377,0.00001099626,0.0001684702,0.005190514,0.0001687723,0.000119462,0.00001286243,0.00005454726,0.001836707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1575471,"threshold_uncertainty_score":0.8158083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985138198965657,"score_gpt":0.3645535093575762,"score_spread":0.3147021273679196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}