{"id":"W3206174963","doi":"10.1016/j.celrep.2021.109929","title":"Stabilized coronavirus spike stem elicits a broadly protective antibody","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Defense Advanced Research Projects Agency; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Energy","keywords":"Coronavirus; Spike Protein; Spike (software development); Coronavirus disease 2019 (COVID-19); Antibody; Biology; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Stem cell; Cell biology; Medicine; Genetics; Outbreak; Computer science; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403097,0.0002746937,0.0002077757,0.0001522502,0.00007857061,0.0002060911,0.0001109718,0.0002460313,0.001246111],"category_scores_gemma":[0.00008592671,0.00009185145,0.0001705887,0.00008761789,0.0001233175,0.0001297358,0.0001792316,0.0003903863,0.0002822057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887048,"about_ca_system_score_gemma":0.0001175895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002283621,"about_ca_topic_score_gemma":0.0005164568,"domain_scores_codex":[0.9999087,0.00001043262,0.000006120791,0.00002164967,0.00003043958,0.00002274087],"domain_scores_gemma":[0.9999502,0.000009062645,0.00001031672,0.000006529335,0.00001134871,0.00001249141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002780334,0.00002432063,0.0001190232,0.00000928515,0.000002252585,0.000009363894,0.000003545595,0.00003112986,0.9987326,0.0000302575,0.00004632849,0.0009640115],"study_design_scores_gemma":[0.00002542541,0.0008589355,0.003926437,0.000004330751,0.00001262695,0.0001585871,0.00001446032,0.0008771261,0.9912421,0.00004440381,0.002833794,0.000001856855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930645,0.000593643,0.003819139,0.0001085335,0.0000294886,0.00003745129,0.0002171817,0.000115219,0.00201492],"genre_scores_gemma":[0.9951357,0.0002953758,0.001638325,0.0001338139,0.00001351174,0.00001889953,0.0005500194,0.0000124322,0.002201846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246111,"threshold_uncertainty_score":0.004168689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985138198965657,"score_gpt":0.3645535093575762,"score_spread":0.3147021273679196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}