{"id":"W3206183296","doi":"10.1016/j.molmed.2021.09.005","title":"Epigenetic priming in neurodevelopmental disorders","year":2021,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canada Research Chairs","keywords":"Epigenetics; Biology; Transcriptome; Priming (agriculture); Neuroscience; Epigenesis; Population; DNA methylation; Genetics; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002621104,0.0006754879,0.001329074,0.0007507476,0.00003623265,0.00001463983,0.000489179,0.0003908515,0.0001193421],"category_scores_gemma":[0.0001084234,0.0006437475,0.0002711552,0.001093802,0.000152195,0.0000022121,0.0003618289,0.0004460939,0.000007751567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007447545,"about_ca_system_score_gemma":0.0002450801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000372791,"about_ca_topic_score_gemma":0.0003764984,"domain_scores_codex":[0.9966715,0.0002967378,0.0009595316,0.001133697,0.0003369378,0.0006015961],"domain_scores_gemma":[0.9990296,0.00002150221,0.0001967012,0.0005985314,0.00002124776,0.0001324156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004903127,0.0001161683,0.0001074973,0.0007703109,0.00005786043,0.0001826438,0.00007097545,0.00002267031,0.001793546,0.00001433668,0.0002974732,0.9965616],"study_design_scores_gemma":[0.00110008,0.0002057561,0.002519835,0.004202332,0.0001249285,0.00006007403,0.0000698808,0.000004277182,0.0001575758,0.00001965024,0.9907125,0.000823059],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0017592,0.9947288,0.00009789132,0.0001075431,0.000360949,0.0003324894,0.00000812676,0.000009985238,0.002595029],"genre_scores_gemma":[0.002283884,0.9946625,0.00056409,0.0002591576,0.00003370149,0.0001355621,0.001420897,0.0001324488,0.0005077626],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9957386,"threshold_uncertainty_score":0.9996014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02640549691220979,"score_gpt":0.3241769748215977,"score_spread":0.2977714779093879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}