{"id":"W3206224016","doi":"10.1038/s41408-021-00561-w","title":"Characteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants","year":2021,"lang":"en","type":"letter","venue":"Blood Cancer Journal","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"Acute promyelocytic leukemia; NPM1; Retinoic acid receptor alpha; Myeloid leukemia; Retinoic acid; Cancer research; Retinoic acid receptor; Leukemia; Myeloid; Hematology; Medicine; Arsenic trioxide; Internal medicine; Biology; Oncology; Immunology; Genetics; Karyotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084637,0.0003668768,0.0004336997,0.0006553109,0.0005414299,0.0004967452,0.0003170134,0.001007012,0.002349727],"category_scores_gemma":[0.001877473,0.0001116283,0.0001963953,0.0007090651,0.0003151408,0.000486637,0.0003376421,0.0006393651,0.0009381057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532369,"about_ca_system_score_gemma":0.0002205275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006600539,"about_ca_topic_score_gemma":0.0005000636,"domain_scores_codex":[0.9996773,0.00004323571,0.00003233835,0.00006633766,0.0000638224,0.0001169916],"domain_scores_gemma":[0.9990847,0.0001921605,0.0002249302,0.00006830489,0.0001185543,0.0003113557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001080108,0.0001742237,0.5389695,0.00004858593,0.00002719502,0.4321411,0.000354827,0.00048415,0.006454509,0.001106884,0.00199223,0.01716671],"study_design_scores_gemma":[0.00002954591,0.0003831364,0.2902992,0.00002280159,0.00003440768,0.7018953,0.0003166601,0.0007602244,0.000536341,0.001113619,0.004579128,0.00002973891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818688,0.001776294,0.0008152917,0.0009509316,0.00009736591,0.00004305109,0.0004009431,0.00004311786,0.01400421],"genre_scores_gemma":[0.9973565,0.0003786424,0.0001556332,0.00025597,0.0002174369,0.00001385641,0.0003028059,0.00001106409,0.001308053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002349727,"threshold_uncertainty_score":0.007860661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054446335079227,"score_gpt":0.2419341986136415,"score_spread":0.2313897352628492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}