{"id":"W3206226697","doi":"10.1016/j.ccell.2021.09.012","title":"Serial assessment of measurable residual disease in medulloblastoma liquid biopsies","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Cancer Research UK; American Lebanese Syrian Associated Charities; National Cancer Institute; Sontag Foundation; St. Baldrick's Foundation","keywords":"Medulloblastoma; Medicine; Minimal residual disease; Biomarker; Oncology; Liquid biopsy; Internal medicine; Prospective cohort study; Cerebrospinal fluid; Surrogate endpoint; Pathology; Cancer; Biology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007718315,0.0001005864,0.000137909,0.00001646056,0.00002230642,0.0000126849,0.00010132,0.00006364901,0.0001375025],"category_scores_gemma":[0.00004449211,0.0001098961,0.00005580383,0.00007390433,0.00004400736,0.000002794403,0.000104151,0.00004669144,0.000001090595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006515782,"about_ca_system_score_gemma":0.0009711662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003077395,"about_ca_topic_score_gemma":0.001868794,"domain_scores_codex":[0.9992372,0.00003415013,0.0001850505,0.0002597813,0.0001090568,0.000174728],"domain_scores_gemma":[0.9994498,0.0000134815,0.0000626039,0.0002692434,0.0001130686,0.00009181082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003357958,0.0001417418,0.01242828,0.00008652811,0.00002149551,0.00002374143,0.00003870632,0.004167764,0.9801328,0.00008888994,0.002290535,0.0002437595],"study_design_scores_gemma":[0.0009406633,0.0001884231,0.01342074,0.00004104711,0.00002811802,8.160525e-7,0.0001033097,0.00008341493,0.957448,0.0000342966,0.02752373,0.0001874473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884474,0.008147954,0.00004669423,0.0001776526,0.0004188,0.00008627523,0.0001848048,0.000003267228,0.002487111],"genre_scores_gemma":[0.9948505,0.003794952,0.000319519,0.0001581932,0.0002940407,0.00003844677,0.00009405016,0.00001649097,0.0004338398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02523319,"threshold_uncertainty_score":0.4481432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009666220055686249,"score_gpt":0.2678091021653936,"score_spread":0.2581428821097074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}