{"id":"W3206226697","doi":"10.1016/j.ccell.2021.09.012","title":"Serial assessment of measurable residual disease in medulloblastoma liquid biopsies","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Cancer Research UK; American Lebanese Syrian Associated Charities; National Cancer Institute; Sontag Foundation; St. Baldrick's Foundation","keywords":"Medulloblastoma; Medicine; Minimal residual disease; Biomarker; Oncology; Liquid biopsy; Internal medicine; Prospective cohort study; Cerebrospinal fluid; Surrogate endpoint; Pathology; Cancer; Biology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001112661,0.0003658321,0.0003343883,0.001593049,0.0002980289,0.0007968947,0.0003954688,0.0003362757,0.001096882],"category_scores_gemma":[0.00152142,0.0002000628,0.0002494748,0.0004894254,0.0002307688,0.0005330112,0.0003279105,0.0005827809,0.0003535063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000621953,"about_ca_system_score_gemma":0.000338262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004760974,"about_ca_topic_score_gemma":0.009398452,"domain_scores_codex":[0.9995714,0.00007002745,0.00003438458,0.00008073803,0.0001715029,0.00007197403],"domain_scores_gemma":[0.9991684,0.000262038,0.0001167396,0.00005510831,0.000271849,0.000125975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003478414,0.0001772217,0.371784,0.0002530723,0.0001611474,0.005271779,0.00073721,0.001803936,0.513072,0.0004385035,0.001051873,0.1017707],"study_design_scores_gemma":[0.00004487889,0.002171121,0.5687315,0.000109344,0.0003791581,0.01079908,0.0008334834,0.0162929,0.3912365,0.0004911389,0.008875743,0.00003518311],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702612,0.008619132,0.01235484,0.0002201977,0.00005808198,0.0001024607,0.0007863429,0.0005380675,0.007059655],"genre_scores_gemma":[0.9912215,0.001078712,0.005293953,0.00006853161,0.00002079699,0.00003754073,0.0005889506,0.00005245994,0.001637539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004760974,"threshold_uncertainty_score":0.009466529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009666220055686249,"score_gpt":0.2678091021653936,"score_spread":0.2581428821097074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}