{"id":"W3206255287","doi":"10.1016/s1474-4422(21)00301-x","title":"Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital; University of Manitoba","funders":"Multiple Sclerosis International Federation; Instituto de Salud Carlos III; Paracelsus Medizinische Privatuniversität; Royan Institute; Multiple Sclerosis Society of Canada; Fondazione Italiana Sclerosi Multipla; French Muscular Dystrophy Association; Multiple Sclerosis Society; Research Manitoba; European Committee for Treatment and Research in Multiple Sclerosis; UK Stem Cell Foundation; Associazione Italiana Sclerosi Multipla; Scleroseforeningen; Bloddonorerne i Danmark; Compagnia di San Paolo; Toyota Foundation","keywords":"Medicine; Tolerability; Clinical endpoint; Multiple sclerosis; Placebo; Expanded Disability Status Scale; Adverse effect; Mesenchymal stem cell; Internal medicine; Clinical trial; Oncology; Surgery; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00213665,0.003285494,0.005861091,0.0006367887,0.0006132509,0.001506545,0.001215068,0.003334949,0.00787611],"category_scores_gemma":[0.002957533,0.001061821,0.002546334,0.0005404828,0.002159558,0.00201203,0.0005612131,0.004087408,0.001419052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007146284,"about_ca_system_score_gemma":0.0007826798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006350617,"about_ca_topic_score_gemma":0.0008059888,"domain_scores_codex":[0.9989437,0.0005313113,0.00007941352,0.000239384,0.00007506584,0.0001311416],"domain_scores_gemma":[0.9986753,0.0004681596,0.0002997487,0.0001207673,0.0001033439,0.000332661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9912521,0.002808603,0.0001294407,0.0003106954,0.0003992892,0.00001667677,0.00003192498,0.0001126907,0.001118745,0.0000551619,0.000197824,0.003566738],"study_design_scores_gemma":[0.9447785,0.05369777,0.0005747312,0.00002119849,0.000245527,0.0000129539,0.00001455218,0.0001593534,0.0001780621,0.000122616,0.0001821679,0.00001249785],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848513,0.006702952,0.00101563,0.0006486815,0.0008707861,0.003507715,0.0009402572,0.0001381979,0.00132443],"genre_scores_gemma":[0.9814721,0.003475552,0.002114759,0.001071334,0.0009762745,0.006339289,0.0009416467,0.00004617952,0.00356291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00787611,"threshold_uncertainty_score":0.02634817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2181256498290405,"score_gpt":0.3748098725244554,"score_spread":0.1566842226954149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}