{"id":"W3206255287","doi":"10.1016/s1474-4422(21)00301-x","title":"Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital; University of Manitoba","funders":"Multiple Sclerosis International Federation; Instituto de Salud Carlos III; Paracelsus Medizinische Privatuniversität; Royan Institute; Multiple Sclerosis Society of Canada; Fondazione Italiana Sclerosi Multipla; French Muscular Dystrophy Association; Multiple Sclerosis Society; Research Manitoba; European Committee for Treatment and Research in Multiple Sclerosis; UK Stem Cell Foundation; Associazione Italiana Sclerosi Multipla; Scleroseforeningen; Bloddonorerne i Danmark; Compagnia di San Paolo; Toyota Foundation","keywords":"Medicine; Tolerability; Clinical endpoint; Multiple sclerosis; Placebo; Expanded Disability Status Scale; Adverse effect; Mesenchymal stem cell; Internal medicine; Clinical trial; Oncology; Surgery; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001872838,0.0002363498,0.001237086,0.000106812,0.0001073025,0.00003332245,0.0002632957,0.0002365675,0.0002887447],"category_scores_gemma":[0.0004576327,0.0001744615,0.0001535435,0.0004158783,0.0004911809,0.00008317612,0.0004038443,0.0008739574,0.00001542574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004730246,"about_ca_system_score_gemma":0.0002816025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002462881,"about_ca_topic_score_gemma":0.0004460996,"domain_scores_codex":[0.9965902,0.0011013,0.0005577494,0.0006032528,0.0005005203,0.0006469555],"domain_scores_gemma":[0.9949428,0.003725169,0.0001791005,0.0008399862,0.000133737,0.0001792345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9128614,0.00078628,0.001820313,0.0001262461,0.00008425188,0.000160997,0.000256184,0.00005879853,0.07971182,0.00003451293,0.0002128496,0.003886373],"study_design_scores_gemma":[0.8932368,0.002203755,0.002388228,0.0000261542,0.0000702312,0.000048379,0.00003197062,0.001574178,0.09900303,0.00002532813,0.001262744,0.0001292146],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889619,0.0002404808,0.00002377991,0.005249007,0.0005484324,0.002668976,0.00003468466,0.00002577744,0.00224694],"genre_scores_gemma":[0.9985351,0.0003350301,0.00002442286,0.0002368566,0.0003596038,0.0001194536,0.000006579049,0.00002628764,0.0003566598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01962459,"threshold_uncertainty_score":0.7114332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2181256498290405,"score_gpt":0.3748098725244554,"score_spread":0.1566842226954149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}