{"id":"W3206271164","doi":"10.1242/bio.058688","title":"Cellular senescence limits translational readthrough","year":2021,"lang":"en","type":"article","venue":"Biology Open","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Cancer Society Research Institute; Cancer Research Society; University of British Columbia; McGill University","keywords":"Senescence; Biology; Carcinogenesis; Suppressor; Cancer; Translation (biology); Cancer research; DNA damage; Cancer cell; Context (archaeology); Cell biology; Genetics; Gene; DNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003424472,0.0003491865,0.0003695327,0.0002322965,0.0001491402,0.0006239961,0.0001964917,0.0002973602,0.0009351841],"category_scores_gemma":[0.000421373,0.0001520897,0.0002963247,0.0001393913,0.0002755785,0.0003825562,0.0004056896,0.00046025,0.0004988306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942352,"about_ca_system_score_gemma":0.0004056416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003028663,"about_ca_topic_score_gemma":0.0003379941,"domain_scores_codex":[0.9997285,0.00004396601,0.00002770718,0.00007908984,0.00007620016,0.00004456681],"domain_scores_gemma":[0.9994586,0.00008551772,0.0001704503,0.00008198411,0.0001127654,0.00009064002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006229333,0.000006057958,0.0002022254,0.00002905838,0.000002132606,0.0000133722,0.00001483728,0.00002958136,0.9982826,0.0001983051,0.00001891059,0.001140761],"study_design_scores_gemma":[0.000009607046,0.0002726473,0.005789375,0.00001339045,0.000008842242,0.0001906502,0.00002979718,0.000761677,0.9872843,0.0003454807,0.005287924,0.000006341397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817712,0.007279758,0.007056725,0.0002260783,0.00007935731,0.0000283285,0.0003626034,0.0002690991,0.002926871],"genre_scores_gemma":[0.9931636,0.001781391,0.002184743,0.00008529901,0.00002359055,0.0000246271,0.000469301,0.00004902347,0.002218518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009351841,"threshold_uncertainty_score":0.003128529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472519332904488,"score_gpt":0.2956532785563104,"score_spread":0.2609280852272655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}