{"id":"W3206271164","doi":"10.1242/bio.058688","title":"Cellular senescence limits translational readthrough","year":2021,"lang":"en","type":"article","venue":"Biology Open","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Cancer Society Research Institute; Cancer Research Society; University of British Columbia; McGill University","keywords":"Senescence; Biology; Carcinogenesis; Suppressor; Cancer; Translation (biology); Cancer research; DNA damage; Cancer cell; Context (archaeology); Cell biology; Genetics; Gene; DNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800102,0.0001058945,0.0001265201,0.000009987963,0.00008878188,0.00002864382,0.0003399436,0.0001977632,0.0002792405],"category_scores_gemma":[0.00005883595,0.0000998451,0.00005776923,0.00005690948,0.0000530959,0.000004182318,0.0001332288,0.00004411941,0.00005998003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002604817,"about_ca_system_score_gemma":0.000152785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001765185,"about_ca_topic_score_gemma":0.00002660524,"domain_scores_codex":[0.9991086,0.0001503665,0.0001401945,0.0003778742,0.00004478448,0.0001782207],"domain_scores_gemma":[0.9995111,0.0000149773,0.00004159071,0.0003149401,0.00006880978,0.00004864235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003507634,0.0000311843,0.001054238,0.000003428545,0.00002969221,0.000008279994,0.00001337702,0.000001232503,0.9886531,0.004131975,0.0006349452,0.005403496],"study_design_scores_gemma":[0.0002168073,0.0000675408,0.0004114469,0.000006178101,0.0000067132,0.00001739853,0.00001342493,0.000002747317,0.7872391,0.001402626,0.210498,0.000117963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7718501,0.01047296,0.1391197,0.007039572,0.001566115,0.001312615,0.0002011194,0.00005598947,0.06838181],"genre_scores_gemma":[0.9829762,0.0002378952,0.01101213,0.0008593326,0.0002398986,0.00004388909,0.0004389283,0.00001616074,0.004175578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2111261,"threshold_uncertainty_score":0.4071565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472519332904488,"score_gpt":0.2956532785563104,"score_spread":0.2609280852272655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}