{"id":"W3206388057","doi":"10.1039/d1ob01653a","title":"Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors","year":2021,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research","keywords":"Kainate receptor; AMPA receptor; Antagonist; Chemistry; Competitive antagonist; Receptor; Pharmacology; Neuroscience; Glutamate receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642596,0.0001799621,0.0002799324,0.00001952572,0.00004956845,0.00001597143,0.0001016145,0.0002156593,0.000144754],"category_scores_gemma":[0.0002004703,0.0001715136,0.00007747132,0.0001071092,0.0002232447,0.000005830007,0.0001457382,0.00007136914,9.767464e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001123481,"about_ca_system_score_gemma":0.00009627768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001305946,"about_ca_topic_score_gemma":0.00000228142,"domain_scores_codex":[0.9989579,0.00008509067,0.0002476086,0.0004035934,0.0001287042,0.0001771589],"domain_scores_gemma":[0.9993896,0.00003193868,0.0001847445,0.0002046805,0.00009367908,0.00009537575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007113598,0.0001252061,0.001915981,0.0001429714,0.0001560173,0.00002759237,0.00003358302,1.927269e-8,0.9953418,0.000002509357,0.00002693324,0.002156262],"study_design_scores_gemma":[0.0002238923,0.00006171177,0.00282403,0.00004070371,0.00009302449,0.0001707134,0.000153665,0.000004851396,0.9956491,0.00001487846,0.0005812038,0.0001822261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978395,0.001035631,0.0006361263,0.0001483713,0.00003166129,0.00006400244,0.00007624974,0.000007794173,0.0001606656],"genre_scores_gemma":[0.9975897,0.001824054,0.0002799942,0.00004736765,0.00004384291,0.000005954339,0.0001316574,0.00001645178,0.00006098255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001974036,"threshold_uncertainty_score":0.6994122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006988080799883731,"score_gpt":0.2270239854819907,"score_spread":0.2200359046821069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}