{"id":"W3206416348","doi":"10.1016/j.bcp.2021.114809","title":"Pathogenic mitochondrial dysfunction and metabolic abnormalities","year":2021,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Mitochondrion; Biology; Mitochondrial disease; mitochondrial fusion; Metabolic pathway; Bioenergetics; Mitochondrial DNA; Disease; Cell biology; Genetics; Metabolism; Biochemistry; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003011643,0.0008330739,0.0008024292,0.001832107,0.0003345336,0.0009438013,0.0005831645,0.0009861571,0.004981196],"category_scores_gemma":[0.0006012975,0.0001508535,0.0003195388,0.0010478,0.0004804898,0.001001988,0.0007665707,0.001502484,0.002970398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005495836,"about_ca_system_score_gemma":0.0007670588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008768489,"about_ca_topic_score_gemma":0.001531085,"domain_scores_codex":[0.9998757,0.00002056635,0.00001500908,0.00002785178,0.00004353095,0.00001743452],"domain_scores_gemma":[0.9998012,0.00006441487,0.00003183037,0.00001062826,0.00006559576,0.00002636868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009387082,0.00004940978,0.0005916924,0.009044437,0.0000910638,0.0008916618,0.00008100132,0.0002973719,0.003549746,0.01073681,0.06846365,0.9061092],"study_design_scores_gemma":[0.0000115671,0.00006583801,0.001172734,0.003136029,0.00009874797,0.00810142,0.00008008997,0.0001108105,0.001268936,0.006018555,0.9799159,0.0000193637],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002148837,0.9958602,0.0003094523,0.0008113207,0.0005066426,0.000004460424,0.00003470446,0.00002183106,0.002236567],"genre_scores_gemma":[0.002744246,0.9936651,0.0002843464,0.000544858,0.0005747832,0.000006317115,0.0001003879,0.000004436214,0.002075569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004981196,"threshold_uncertainty_score":0.01666373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02830654019440361,"score_gpt":0.3202722661092713,"score_spread":0.2919657259148677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}