{"id":"W3206421483","doi":"10.1139/cjpp-2021-0329","title":"The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Key Research and Development Projects of Shaanxi Province; Education Department of Shaanxi Province; National Natural Science Foundation of China","keywords":"RANKL; Osteoprotegerin; Calcification; Internal medicine; Endocrinology; Common carotid artery; Osteopontin; Receptor; Medicine; Chemistry; Carotid arteries; Activator (genetics)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005626759,0.0001545711,0.0006145216,0.0001600882,0.0001524649,0.000006551135,0.0001238558,0.0002554665,0.00006228],"category_scores_gemma":[0.00007451323,0.000117177,0.00008988738,0.0002227332,0.0004024934,0.0000405457,0.00001708273,0.0004750126,0.000001570194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273337,"about_ca_system_score_gemma":0.0005757595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008736385,"about_ca_topic_score_gemma":0.001896766,"domain_scores_codex":[0.9979911,0.0008265788,0.0005640363,0.0002004023,0.00005619455,0.0003616704],"domain_scores_gemma":[0.9982926,0.0006055637,0.0003711066,0.0001612608,0.0002873626,0.0002820731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002413608,0.00004353532,0.01848365,0.0001389994,0.0001839785,0.0001565871,0.0002629125,0.0001772636,0.9787549,0.00007814979,0.0009094044,0.0005692081],"study_design_scores_gemma":[0.002299943,0.0004672981,0.0431295,0.0001174437,0.0001285631,0.0009809993,0.0002683328,0.001167126,0.9500532,0.0001532566,0.001114871,0.0001194385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931383,0.004011043,0.00000690769,0.001842343,0.0006720208,0.0002470604,0.00002920157,0.000005306246,0.00004784173],"genre_scores_gemma":[0.9992269,0.0001231613,0.00004020189,0.0003830419,0.0001397752,0.000004328325,0.00003597644,0.00001284379,0.00003379397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02870172,"threshold_uncertainty_score":0.4778341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125835174735001,"score_gpt":0.271853391515517,"score_spread":0.260595039768167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}