{"id":"W3206421483","doi":"10.1139/cjpp-2021-0329","title":"The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Key Research and Development Projects of Shaanxi Province; Education Department of Shaanxi Province; National Natural Science Foundation of China","keywords":"RANKL; Osteoprotegerin; Calcification; Internal medicine; Endocrinology; Common carotid artery; Osteopontin; Receptor; Medicine; Chemistry; Carotid arteries; Activator (genetics)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456712,0.0008732862,0.0005107874,0.0006922411,0.0002703008,0.0004053477,0.0002756954,0.0004197153,0.001273438],"category_scores_gemma":[0.000160888,0.0003681903,0.0006102084,0.0002038388,0.0005985373,0.000387849,0.0003525529,0.001254187,0.0001966722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168598,"about_ca_system_score_gemma":0.0004047656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202188,"about_ca_topic_score_gemma":0.001854438,"domain_scores_codex":[0.9997383,0.00003581612,0.00002728085,0.00005597069,0.000056583,0.00008604057],"domain_scores_gemma":[0.9998068,0.000007425975,0.00006923675,0.00002012976,0.00002038338,0.00007606149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00164139,0.0002601274,0.0007847985,0.000123498,0.00003085713,0.0001066019,0.00009236606,0.0001227283,0.9937739,0.0001186689,0.0000678357,0.00287727],"study_design_scores_gemma":[0.0003119692,0.006905466,0.03329702,0.00005054031,0.0002697583,0.0003875363,0.0003651303,0.00300775,0.9514997,0.0003546163,0.00350337,0.00004724048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952931,0.001902007,0.001926584,0.0001312363,0.00005257325,0.00002808231,0.0001765218,0.00007693374,0.0004128625],"genre_scores_gemma":[0.9927171,0.001849288,0.002087859,0.00008908294,0.00003455786,0.0001392144,0.0003464189,0.00001463367,0.002721695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273438,"threshold_uncertainty_score":0.004260004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125835174735001,"score_gpt":0.271853391515517,"score_spread":0.260595039768167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}