{"id":"W3206427606","doi":"10.1007/s40257-021-00650-3","title":"Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug","year":2021,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; Ortho Dermatologics","keywords":"Adapalene; Tolerability; Medicine; Benzoyl peroxide; Acne; Clindamycin; Adverse effect; Dermatology; Internal medicine; Randomized controlled trial; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002627035,0.001808379,0.002831735,0.0006167978,0.0005466806,0.001175195,0.001172661,0.002015952,0.004679304],"category_scores_gemma":[0.001715327,0.001144076,0.001649372,0.0004293372,0.001402884,0.001250866,0.0003987928,0.003194245,0.0009498498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008276346,"about_ca_system_score_gemma":0.001401871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000562405,"about_ca_topic_score_gemma":0.001297768,"domain_scores_codex":[0.9989167,0.0005145337,0.00007347693,0.0002423769,0.0001176219,0.0001352818],"domain_scores_gemma":[0.9982254,0.0003637724,0.0004688604,0.0001762118,0.0001524436,0.0006133215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8826706,0.07222994,0.0009907602,0.0005248628,0.0006334696,0.00004270172,0.000102049,0.0003459392,0.02330001,0.00006801989,0.0004647803,0.01862675],"study_design_scores_gemma":[0.577552,0.416565,0.002249632,0.00002005921,0.0004202998,0.00005230376,0.00002795353,0.0004017188,0.00221277,0.00005844034,0.000419945,0.00001995222],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924626,0.001471542,0.0006663964,0.0001962197,0.0001809196,0.003820534,0.0004535468,0.00006557756,0.0006826636],"genre_scores_gemma":[0.9914224,0.00103589,0.001874626,0.0003626827,0.000245538,0.003183313,0.0003811267,0.00002349827,0.001471002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004679304,"threshold_uncertainty_score":0.01565379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119172039085781,"score_gpt":0.3577893671948569,"score_spread":0.3365976468039991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}