{"id":"W3206427606","doi":"10.1007/s40257-021-00650-3","title":"Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug","year":2021,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; Ortho Dermatologics","keywords":"Adapalene; Tolerability; Medicine; Benzoyl peroxide; Acne; Clindamycin; Adverse effect; Dermatology; Internal medicine; Randomized controlled trial; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090565,0.0002023092,0.002535645,0.00009142986,0.0001617801,0.000008604347,0.0001115863,0.00008728813,0.00001386605],"category_scores_gemma":[0.002009684,0.0001182963,0.0003846716,0.000236995,0.0004747343,0.00006870845,0.0001113418,0.0002952685,3.759836e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001342404,"about_ca_system_score_gemma":0.0002454421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002789222,"about_ca_topic_score_gemma":0.00002547571,"domain_scores_codex":[0.9967051,0.0006734075,0.00190902,0.0002623394,0.0002375864,0.0002125875],"domain_scores_gemma":[0.9943666,0.00332572,0.001376599,0.0002497832,0.0004506953,0.0002305773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7950015,0.02044771,0.06833462,0.0003449894,0.004112126,0.0004050617,0.007573958,0.0001031469,0.0003638482,0.000191923,0.00180091,0.1013202],"study_design_scores_gemma":[0.9105812,0.01689116,0.05939214,0.0005360493,0.00285058,0.00154349,0.002743126,0.00171245,0.002348177,0.0001801159,0.0009949848,0.0002265036],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896606,0.0009767468,0.0002443549,0.007539843,0.0002277285,0.001309302,0.00001551583,0.000004193725,0.00002168956],"genre_scores_gemma":[0.997243,0.0009195842,0.0007237354,0.0009295029,0.00005073495,0.00001731377,0.000004480178,0.00001807183,0.00009356012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1155797,"threshold_uncertainty_score":0.4823982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119172039085781,"score_gpt":0.3577893671948569,"score_spread":0.3365976468039991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}