{"id":"W3206434489","doi":"10.1021/acschembio.1c00576","title":"Concerted Differential Changes of Helical Dynamics and Packing upon Ligand Occupancy in a Bacterial Chemoreceptor","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Richard and Susan Smith Family Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation","keywords":"Periplasmic space; Coiled coil; Biophysics; Transmembrane domain; Ligand (biochemistry); Helix (gastropod); Transmembrane protein; PAS domain; Protein structure; Histidine kinase; Conformational change; Förster resonance energy transfer; Cytoplasm; Chemistry; Crystallography; Receptor; Biology; Histidine; Biochemistry; Amino acid; Escherichia coli; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248619,0.0000928439,0.0002842945,0.0001195358,0.0001749726,0.0003608892,0.0001917451,0.0002206345,0.0003860054],"category_scores_gemma":[0.0002248053,0.0001599423,0.0001155056,0.00009338945,0.0002822148,0.0002798329,0.000152338,0.0002898097,0.0001601648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209136,"about_ca_system_score_gemma":0.0001262556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003821695,"about_ca_topic_score_gemma":0.0005194292,"domain_scores_codex":[0.9999101,0.00001220878,0.000005538004,0.00002105798,0.000024991,0.00002612733],"domain_scores_gemma":[0.9998593,0.00003490248,0.0000323546,0.00001174621,0.000016076,0.00004561464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009442621,0.0000134962,0.0004865988,0.00001157092,0.000003855833,0.00003673236,0.00003188938,0.0001665388,0.9986246,0.00007214655,0.00001252545,0.0004457012],"study_design_scores_gemma":[0.00003289344,0.0003181374,0.03365875,0.000008310058,0.00002300201,0.0003166542,0.000214879,0.01471611,0.9499664,0.0002014979,0.0005060566,0.0000373456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999615,0.00004503387,0.0002156918,0.0000138027,0.000001952134,0.0000012332,0.0000120107,0.000006581916,0.00008873689],"genre_scores_gemma":[0.9995844,0.00004603104,0.0002326325,0.00001599711,0.000001506132,0.00000259155,0.00002747208,0.000003664366,0.00008569006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003860054,"threshold_uncertainty_score":0.002328396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008565020511218574,"score_gpt":0.2396160065396903,"score_spread":0.2310509860284717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}