{"id":"W3206434489","doi":"10.1021/acschembio.1c00576","title":"Concerted Differential Changes of Helical Dynamics and Packing upon Ligand Occupancy in a Bacterial Chemoreceptor","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Richard and Susan Smith Family Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation","keywords":"Periplasmic space; Coiled coil; Biophysics; Transmembrane domain; Ligand (biochemistry); Helix (gastropod); Transmembrane protein; PAS domain; Protein structure; Histidine kinase; Conformational change; Förster resonance energy transfer; Cytoplasm; Chemistry; Crystallography; Receptor; Biology; Histidine; Biochemistry; Amino acid; Escherichia coli; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005635732,0.0001790745,0.000352422,0.00003930023,0.00001774941,0.00001051177,0.000150293,0.0007305763,0.00004609119],"category_scores_gemma":[0.0001509789,0.0001657767,0.00004808331,0.00009754262,0.0002505906,0.000001509934,0.0003729234,0.0001482907,0.000001041804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001479838,"about_ca_system_score_gemma":0.00005217269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001536187,"about_ca_topic_score_gemma":0.0001746922,"domain_scores_codex":[0.9988815,0.00005156151,0.0002658372,0.0004579677,0.00004309716,0.0003000849],"domain_scores_gemma":[0.9995212,0.00002400216,0.00009056519,0.0002348579,0.00006638961,0.00006296622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002238248,0.00007631148,0.003200171,0.00002247899,0.00003560102,0.000003067411,0.00001344427,3.027343e-8,0.9853499,0.000295192,0.00002389524,0.01075607],"study_design_scores_gemma":[0.001079069,0.0002270281,0.001276775,0.0000168365,0.00001475216,0.00002912071,0.00002398017,0.00003430436,0.9950698,0.0001248382,0.001919136,0.0001843788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983945,0.0004437228,0.0000559986,0.0005969062,0.0002591376,0.00009310548,0.0001010954,0.000009604252,0.00004593743],"genre_scores_gemma":[0.9975504,0.0007725264,0.000314323,0.0001021196,0.0002855662,0.00001193393,0.0009294812,0.00001492268,0.00001872703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01057169,"threshold_uncertainty_score":0.6760176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008565020511218574,"score_gpt":0.2396160065396903,"score_spread":0.2310509860284717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}